Alzheimer's disease is an irreversible,age-related neurodegenerative disease that is currently still an incurable disease.Autophagy can play neuroprotective role by promoting the clearance of amyloid β and reducing Tau protein phosphorylation.Active ingredients of traditional Chinese medicine can intervene in Alzheimer's disease through autophagy induction stage,autophagosome extension stage,autophagosome processing stage,and mitochondrial autophagy.This article explores the research progress of active ingredients in traditional Chinese medicine intervening in Alzheimer's disease by regulating autophagy,in order to provide reference for the clinical application of traditional Chinese medicine in treatment of Alzheimer's disease.
关键词
中药活性成分/阿尔茨海默病/自噬诱导/自噬泡延伸/自噬体加工/线粒体自噬
Key words
active ingredients of traditional Chinese medicine/Alzheimer's disease/autophagy induction/autophagosome extension/autophagosome process/mitochondrial autophagy
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