Depression is a common mental disorder with complex pathogenesis,and there is currently a lack of effective cure drugs.Baicalin is a natural flavonoid extracted from Scutellariae Radix,which has various pharmacological effects.Baicalin can exert antidepressant effects by promoting neurogenesis,enhancing synaptic plasticity,regulating the HPA axis,reducing neuroinflammatory responses,inhibiting neuronal cell apoptosis,and improving mitochondrial function.This paper summarized the research progress on the antidepressant effect of baicalin,analyzed its mechanism of action,and provided evidence-based support for the clinical application of baicalin.
关键词
黄芩苷/抑郁/神经发生/神经突触可塑性/HPA轴/神经炎症反应/神经细胞凋亡/线粒体功能
Key words
baicalin/depression/neurogenesis/synaptic plasticity/HPA axis/neuroinflammatory response/neuronal cell apoptosis/mitochondrial function
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