Value of LA,CRP,and AT-Ⅲ in predicting unexpected recurrent spontaneous abortion
Objective To explore the predictive value of serum lupus anticoagulant(LA),C-reactive protein(CRP),and an-tithrombin Ⅲ(AT-Ⅲ)in unexplained recurrent spontaneous abortion(URSA).Methods Eighty-two patients with URSA admitted to our hospital from January 2022 to August 2023 were selected as the URSA group,and 60 healthy pregnant women without a history of miscarriage were selected as controls.The serum LA ratio,CRP level,and AT-Ⅲ activity were compared between the two groups.The predictive value of serum LA,CRP,AT-Ⅲ,and their combination for URSA was analyzed using the receiver operating characteristic(ROC)curve analysis.The serum LA ratio,CRP level,AT-Ⅲ activity,and the positive rates of LA,CRP,and AT-Ⅲ were compared among different groups based on the number of miscarriages(2 miscarriages group,3 miscarriages group,4 miscarriages or above group).Results The serum LA ratio and CRP level in the URSA group were significantly higher than those in the control group(P<0.05),while the AT-Ⅲ activity was sig-nificantly lower in the URSA group than that in the control group(P<0.05).The areas under the curve(AUC)for predic-ting URSA were 0.788(95%CI:0.713-0.862)for LA,0.790(95%CI:0.718-0.863)for CRP,and 0.855(95%CI:0.794-0.916)for AT-Ⅲ,with cutoff values of 1.33,6.39 mg/L,and 82.37%,respectively.The AUC for the com-bined detection of LA,CRP,and AT-Ⅲ in predicting URSA was 0.962(95%CI:0.936-0.988),which was significantly higher than the AUC for the individual predictors(P<0.05).Significant differences were observed in the LA ratio and CRP level among different groups based on the number of miscarriages(P<0.05).The LA ratio was significantly higher in the 4 miscarriages or above group and 3 miscarriages group compared to the 2 miscarriages group(P<0.05),and the CRP level was significantly higher in the 4 miscarriages or above group compared to the 2 miscarriages group and 3 miscarriages group(P<0.05).Significant differences were found in the positive rates of LA,CRP,and AT-Ⅲ among different groups based on the number of miscarriages(P<0.05).Conclusion The serum LA ratio and CRP level were elevated,while AT-Ⅲ ac-tivity was decreased in patients with URSA.LA,CRP,and AT-Ⅲ demonstrate predictive value for URSA,and the value is strengthened when these indicators are combined.
Lupus anticoagulantC-reactive proteinAntithrombinUnexpected recurrent spontaneous abortionPredictive value
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