Application of ketamine patient-controlled analgesia in parturient women after cesarean section
Objective To explore the application value of ketamine patient-controlled analgesia(PCA)in postpartum women after cesarean section to provide evidence for clinical treatment.Methods A total of 104 postpartum women who underwent cesarean section and were admitted to Nanjing Lishui People's Hospital from February 2020 to March 2023 were selected as the research participants.They were allocated to a control group and an observation group using a random number table,with 52 cases in each group.After the surgery,the women were sent to the post-anesthesia care unit and connected to an in-travenous electronic patient-controlled analgesia pump for PCA.The control group received conventional analgesia,while the observation group received ketamine for analgesia.The visual analog scale(VAS)was used to assess the pain levels of the two groups of women at 2 hours,6 hours,12 hours,24 hours,and 48 hours after delivery.The rescue analgesia rate and number of pump presses within 48 hours after surgery were compared between the two groups.The levels of norepinephrine(NE),cortisol(FC),atrial natriuretic peptide(ANP),and epinephrine(E)in the two groups of women before and 24 hours after delivery were compared.The occurrence of adverse reactions in the two groups of women after delivery was also compared.Results The VAS scores of the observation group at 2 hours,6 hours,12 hours,24 hours,and 48 hours after delivery were significantly lower than those of the control group(P＜0.05).No significant difference was observed in the rescue analgesia rate and number of pump presses between the two groups(P＞0.05).Before delivery,no significant differ-ence was found in the levels of NE,FC,ANP,and E between the two groups of women(P＞0.05).After 24 hours,the levels of NE,FC,ANP,and E in both groups of women significantly increased compared to before delivery(P＜0.05),while the levels of NE,FC,ANP,and E in the observation group were significantly lower than those in the control group(P＜0.05).No significant difference was noted in the occurrence of adverse reactions between the two groups of women(P＞0.05).Conclusion Ketamine PCA has a marked analgesic effect in postpartum women after cesarean section,can reduce ma-ternal stress response,and does not increase the occurrence of adverse reactions,with a good safety profile,which holds promise for a wider application for postpartum women after cesarean section.
万方数据
维普
