Changes in serum Pro-GRP and NSE levels before and after chemotherapy in non-small cell lung cancer and their clinical significance
Objective To analyze the changes in serum levels of pro-gastrin-releasing peptide(Pro-GRP)and neuron-specific enolase(NSE)before and after chemotherapy in non-small cell lung cancer(NSCLC)and their clinical significance.Methods A total of 126 NSCLC patients admitted to our hospital from February 2020 to February 2022 were selected as the observa-tion group,and 108 healthy individuals who underwent physical examinations at our hospital during the same period were se-lected as controls.The levels of Pro-GRP and NSE in the observation group and the control group were compared,and the changes in Pro-GRP and NSE levels before and after chemotherapy in the observation group were analyzed.The risk factors affecting the efficacy of chemotherapy in NSCLC patients were analyzed.The predictive value of Pro-GRP,NSE,and com-bined detection for the efficacy of chemotherapy in NSCLC patients was analyzed.Results The levels of Pro-GRP and NSE in the observation group before chemotherapy were significantly higher than those in the control group(t=11.584,P＜0.001;t=4.951,P＜0.001).The levels of Pro-GRP and NSE in the observation group before chemotherapy were signifi-cantly higher than those after chemotherapy(t=5.901,P＜0.001;t=2.633,P=0.008).After chemotherapy,there were 98 patients in the effective group and 28 patients in the ineffective group;the differences in smoking history,history of chronic diseases,distant metastasis,Pro-GRP levels,and NSE levels between the two groups were statistically significant(P＜0.05).Logistic regression analysis showed that smoking history,history of chronic diseases,distant metastasis,ele-vated Pro-GRP,and elevated NSE were risk factors for the efficacy of chemotherapy in NSCLC patients(P＜0.05).The receiver operating characteristic(ROC)curve analysis showed that the area under the curve(AUC)for the prediction of chemotherapy efficacy in NSCLC patients using Pro-GRP+NSE was 0.911(95％CI:0.861-0.962),with a sensitivity and specificity of 0.871 and 0.862,respectively.Conclusion Serum Pro-GRP and NSE levels decrease after chemotherapy in NSCLC patients,and the levels of Pro-GRP and NSE can be used to predict the efficacy of chemotherapy.The predictive value is higher when both indicators are combined.
Pro-gastrin-releasing peptideNeuron-specific enolaseNon-small cell lung cancerBefore and after chemotherapy
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