Relationship between high-sensitivity C-reactive protein,cystatin C,and cardiac and renal function injury in patients with septic shock
Objective This paper aims to measure the levels of high-sensitivity C-reactive protein(hs-CRP)and cystatin C(Cys C)in patients with septic shock and explore their relationship with cardiac and renal function injury.Methods Fifty patients with septic shock admitted to our hospital from May 2020 to December 2023 were selected as the shock group.An-other 48 healthy individuals undergoing routine health checks during the same period were selected as the reference group.The hs-CRP and Cys C levels were compared between the two groups.The relationship between serum hs-CRP and Cys C levels with left ventricular ejection fraction(LVEF),early diastolic mitral inflow velocity(E)/early diastolic mitral annular velocity(E'),brain natriuretic peptide(BNP),cardiac troponin Ⅰ(cTnl),glomerular filtration rate(GFR),and Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score in patients with septic shock was analyzed.Results No statistically significant differences were found between the two groups in terms of age,gender distribution,body mass index(BMI),and prevalence of underlying diseases(P＞0.05).The serum hs-CRP levels[(181.01±37.39)mg/L]and serum Cys C levels[(2.62±0.25)mg/L]in the shock group were significantly higher than those in the reference group[(38.78±10.55)mg/L and(0.96±0.15)mg/L;P＜0.05].In the shock group,serum hs-CRP levels were related to LVEF,E/E',BNP,cTnI levels,and APACHE Ⅱ score(P＜0.05),but not related to GFR(P＞0.05);serum Cys C levels were related to GFR levels and APACHE Ⅱ score(P＜0.05),but not related to LVEF,E/E',BNP,and cTnI levels(P＞0.05).Con-clusion The hs-CRP and Cys C levels in patients with septic shock are significantly higher than those in healthy individuals,suggesting a potential link to myocardial cell damage,elevated inflammatory factor levels,and reduced renal blood flow.These parameters can serve as reference indicators for assessing cardiac and renal function injury in these patients.
Septic shockHigh-sensitivity C-reactive proteinCystatin CCardiac functionRenal function
万方数据
维普
