Efficacy and safety of kidney-tonifying Chinese medicine combined with bisphosphonates for treating bone metastases of malignant tumors:a meta-analysis
Efficacy and safety of kidney-tonifying Chinese medicine combined with bisphosphonates for treating bone metastases of malignant tumors:a meta-analysis
Objective This study systematically evaluates the efficacy and safety of kidney-tonifying Chinese medicine com-bined with bisphosphonates in treating bone metastases of malignant tumors,aiming to provide evidence for clinical treat-ment.Methods Databases including CNKI,CBM,VIP,and Wanfang Data were searched for randomized controlled trials(RCTs)involving kidney-tonifying Chinese medicine combined with bisphosphonates for treating bone metastases up to May 5,2023.The quality of included studies was assessed using the Cochrane risk of bias tool,and Meta-analysis was performed using RevMan 5.3 software.Results Eighteen clinical studies were included,with a total sample size of 1 213 cases,594 in the control group and 619 in the treatment group.The treatment group showed significant improvements in progression-free survival for bone metastases,treatment efficacy for bone lesions,pain relief,NRS pain scores,KPS scores,activity levels,blood calcium levels,and adverse event rates compared to the control group(P＜0.05).No significant difference was ob-served in alkaline phosphatase levels between the two groups before and after treatment(P＞0.05).Conclusion Kidney-tonifying Chinese medicine combined with bisphosphonates can inhibit the progression of bone metastases,reduce pain caused by bone metastases,increase quality of life and activity levels,and reduce blood calcium levels and adverse event rates.This demonstrates a clinical significance in treating bone metastases of malignant tumors from a kidney-tonifying per-spective.
关键词
补肾中药/恶性肿瘤骨转移/安全性
Key words
Kidney-tonifying Chinese medicine/Bone metastases of malignant tumors/Safety
维普
万方数据