首页|益生菌联合肠内营养支持方案对老年脑梗死患者肠道菌群、营养指标的影响

益生菌联合肠内营养支持方案对老年脑梗死患者肠道菌群、营养指标的影响

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目的 探讨益生菌联合肠内营养支持方案对老年脑梗死患者肠道菌群、营养指标和不良反应发生率的影响,以期为临床治疗提供参考.方法 选取成都上锦南府医院2022年4月-2023年4月收治的95例老年脑梗死患者为研究对象.采用随机数字表法将患者分为益生菌组(n=48)和常规组(n=47).在脑梗死发病后48 h内,给予常规组患者常规肠内营养支持方案;益生菌组患者则使用益生菌联合肠内营养支持方案进行干预.比较干预前、干预2周时2组患者肠道菌群情况;比较干预前、干预2周时2组患者胃泌素(GAS)、胃动素(MTL)、清蛋白(ALB)、前清蛋白(PAB)水平;比较2组患者干预期间消化道不良反应发生情况.结果 干预前,2组患者粪便中乳杆菌、肠杆菌、肠球菌数量比较,差异无统计学意义(P>0.05).干预后,2组患者粪便中乳杆菌数量高于干预前,且益生菌组高于常规组,差异均有统计学意义(P<0.05).干预后,2组患者粪便中肠杆菌、肠球菌数量均低于干预前,且益生菌组低于常规组,差异均有统计学意义(P<0.05).干预前,2组患者GAS、MTL水平比较,差异无统计学意义(P>0.05).干预后,2组患者GAS、MTL水平均高于干预前,且益生菌组高于常规组,差异均有统计学意义(P<0.05).干预前,2组患者ALB、PAB水平比较,差异无统计学意义(P>0.05).干预后,2组患者ALB、PAB水平均高于干预前,且益生菌组高于常规组,差异均有统计学意义(P<0.05).益生菌组患者不良反应发生率低于常规组,差异有统计学意义(P<0.05).结论 益生菌联合肠内营养支持方案能维持老年脑梗死患者肠道菌群平衡,增强其胃肠功能,改善其营养指标,同时还能降低其不良反应发生率,对患者预后有利,具有一定临床价值.
Effect of probiotics combined with enteral nutrition support on intestinal flora and nutritional indicators in elderly patients with cerebral infarction
Objective This study investigates the impact of probiotics combined with enteral nutrition support on the intesti-nal flora,nutritional indicators,and incidence of adverse reactions in elderly patients with cerebral infarction,aiming to pro-vide a reference for clinical treatment.Methods Ninety-five elderly patients with cerebral infarction admitted to Chengdu Shangjin Nanfu Hospital from April 2022 to April 2023 were selected as subjects.They were randomly assigned to the pro-biotic group(n=48)and the conventional group(n=47).The conventional group received a standard enteral nutrition sup-port regimen within 48 hours after the onset of cerebral infarction,while the probiotic group was treated with probiotics combined with enteral nutrition support.The intestinal flora was assessed before and two weeks after the intervention,and the levels of gastrin(GAS),motilin(MTL),albumin(ALB),and prealbumin(PAB)were compared between the two groups.The incidence of gastrointestinal adverse reactions during the intervention period was also compared.Results Be-fore the intervention,no significant differences were noted in the levels of lactobacilli,enterobacteria,and enterococci in the feces between the two groups(P>0.05).After the intervention,the number of lactobacilli in the feces of both groups in-creased,with the probiotic group showing a significantly higher increase than the conventional group(P<0.05).The levels of enterobacteria and enterococci in the feces decreased in both groups after the intervention,with the probiotic group show-ing a significantly greater reduction compared to the conventional group(P<0.05).No significant differences were found in the levels of GAS and MTL between the two groups before the intervention(P>0.05).After the intervention,the levels of GAS and MTL were higher in both groups,with the probiotic group showing significantly higher levels compared to the con-ventional group(P<0.05).Similarly,the levels of ALB and PAB increased in both groups after the intervention,with the probiotic group showing significantly higher levels compared to the conventional group(P<0.05).The incidence of adverse reactions was significantly lower in the probiotic group compared to the conventional group(P<0.05).Conclusion Probi-otics combined with enteral nutrition support can maintain the balance of intestinal flora,promote gastrointestinal function,and improve nutritional indicators in elderly patients with cerebral infarction.Additionally,it reduces the incidence of ad-verse reactions,positively influencing patient prognosis,and holds certain clinical value.

Enteral nutrition supportCerebral infarctionIntestinal floraNutritional indicatorsElderly

田丽华、曾玉萍、汪莉、姚敏、杨欢

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成都上锦南府医院/四川大学华西医院上锦医院神经内科,成都 610000

肠内营养支持方案 脑梗死 肠道菌群 营养指标 老年

四川省中医药管理局科研课题

2021MS385

2024

保健医学研究与实践
西南大学

保健医学研究与实践

CSTPCD
影响因子:0.512
ISSN:1673-873X
年,卷(期):2024.21(3)