Clinical characteristics of girls with idiopathic premature thelarche and influencing factors for progression to central precocious puberty
Objective To investigate the clinical characteristics of girls with idiopathic premature thelarche (IPT) and the in-fluencing factors for progression to central precocious puberty (CPP).Methods A total of 85 girls with IPT,first diag-nosed at our hospital between January 2017 and December 2021,were selected as the study participants,who were assigned to a progression group and a non-progression group based on whether they progressed to CPP within one year.Clinical fol-low-up data of the two groups were compared.Logistic regression was used to identify independent influencing factors for IPT progression to CPP,and ROC curves were used to assess the predictive value of related indicators for CPP progression.Results Among all participants,20 cases progressed to CPP within one year,with an incidence rate of 23.5％.The pro-gression group showed younger age at onset,higher standard deviation scores for height,weight,and BMI,higher propor-tion of Tanner stage 3,higher bone age-to-chronological age ratio,longer uterine length,and higher blood IGF-1 levels com-pared to the non-progression group,all with statistical significance (P<0.05).Mothers of the progression group had a sig-nificantly earlier age at menarche than those of the non-progression group (P<0.05).Logistic regression analysis indicated that the Tanner stage,blood IGF-1 level,and uterine length were independent influencing factors for IPT progression to CPP (P<0.05).ROC curve analysis indicated that IGF-1 level and uterine length at initial diagnosis had high predictive val-ue for CPP progression within one year,with AUCs of 0.789 and 0.729,respectively (P<0.05).Conclusion Progression from IPT to CPP is not uncommon in girls and is associated with the Tanner stage,blood IGF-1 level,and uterine length.Therefore,close follow-up and intervention for high-risk patients are necessary.
万方数据
维普
