保健医学研究与实践2024,Vol.21Issue(4) :61-66.DOI:10.11986/j.issn.1673-873X.2024.04.011

阴式子宫瘢痕妊娠病灶切除联合子宫修补术治疗Ⅱ型/Ⅲ型剖宫产瘢痕妊娠患者的临床疗效

Clinical efficacy of vaginal scar pregnancy lesion resection combined with uterine repair for type Ⅱ/Ⅲ cesarean scar pregnancy patients

李燕 耿媛媛 董君 孙文妹 姚秀玲
保健医学研究与实践2024,Vol.21Issue(4) :61-66.DOI:10.11986/j.issn.1673-873X.2024.04.011

阴式子宫瘢痕妊娠病灶切除联合子宫修补术治疗Ⅱ型/Ⅲ型剖宫产瘢痕妊娠患者的临床疗效

Clinical efficacy of vaginal scar pregnancy lesion resection combined with uterine repair for type Ⅱ/Ⅲ cesarean scar pregnancy patients

李燕 1耿媛媛 2董君 3孙文妹 1姚秀玲1
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作者信息

  • 1. 河北省衡水市第二人民医院妇科,河北衡水 053000
  • 2. 河北省衡水市第二人民医院产科,河北衡水 053000
  • 3. 衡水卫生学校附属医院不孕不育科,河北衡水 053000
  • 折叠

摘要

目的 分析阴式子宫瘢痕妊娠病灶切除联合子宫修补术治疗Ⅱ型/Ⅲ型剖宫产瘢痕妊娠(CSP)患者的临床疗效及对患者术后恢复的影响,以期为临床制定CSP的治疗方案提供参考.方法 回顾性选取2018年6月—2020年6月衡水市第二人民医院收治的103例Ⅱ型/Ⅲ型CSP患者,根据治疗方式不同分为对照组(50例)和研究组(53例).对照组患者采用子宫动脉化疗栓塞术联合超声引导下清宫术治疗,研究组患者采用阴式子宫瘢痕妊娠病灶切除联合子宫修补术治疗.比较2组患者的临床疗效、手术指标、术后恢复情况以及治疗前后的孕酮、β-人绒毛膜促性腺激素(β-HCG)水平,同时比较2组患者随访2年的子宫瘢痕妊娠复发及正常妊娠情况.结果 研究组患者的治疗总有效率为90.56%(48/53),高于对照组的74.00%(37/50),差异有统计学意义(x2=4.896,P=0.027).2组患者治疗前孕酮及β-HCG水平比较,差异无统计学意义(P>0.05);2组患者治疗后孕酮及β-HCG水平均低于治疗前,且研究组均低于对照组,差异均有统计学意义(P<0.05).研究组患者术中出血量少于对照组,手术时间长于对照组,下床时间、住院时间均短于对照组,差异均有统计学意义(P<0.05).研究组患者术后正常月经恢复时间、阴道出血时间、β-HCG恢复正常时间、宫腔肿块消失时间均短于对照组患者,差异均有统计学意义(P<0.05).研究组患者随访2年子宫瘢痕妊娠复发率为0(0/53),低于对照组患者的14.00%(7/50),差异有统计学意义(x2=5.904,P=0.015).研究组患者随访2年正常妊娠率为66.04%(35/53),高于对照组34.00%(17/50),差异有统计学意义(x2=10.564,P=0.001).结论 阴式子宫瘢痕妊娠病灶切除联合子宫修补术治疗Ⅱ型/Ⅲ型CSP患者疗效显著,可减少患者术中出血量,促进患者术后恢复,且降低子宫瘢痕妊娠复发风险,提高正常妊娠率.

Abstract

Objective To analyze the clinical efficacy of vaginal scar pregnancy lesion resection combined with uterine repair in treating patients with Type Ⅱ/Ⅲ cesarean scar pregnancy (CSP) and its impact on postoperative recovery,providing sup-port for clinical treatment plans for CSP patients.Methods This retrospective study selected 103 Type Ⅱ/Ⅲ CSP patients treated in our hospital from June 2018 to June 2020.Patients were assigned to control group (50 cases) study group (53 ca-ses) based on different treatment methods.The control group underwent uterine artery chemoembolization combined with ultrasound-guided curettage,while the study group received vaginal scar pregnancy lesion resection combined with uterine repair.Clinical efficacy,surgical indicators,postoperative recovery,pre-and post-treatment progesterone,and β-HCG lev-els were compared between the two groups.Additionally,the recurrence of cesarean scar pregnancy and normal pregnancy rates were compared during a two-year follow-up.Results The overall response rate in the study group was significantly higher than that in the control group[90.56% (48/53) vs.74.00% (37/50);x2=4.896,P=0.027].There was no sig-nificant difference in progesterone and β-HCG levels between the two groups before treatment (P>0.05).Post-treatment,both progesterone and β-HCG levels were significantly lower in the study group compared to the control group (P<0.05).The study group had less intraoperative blood loss,longer time of operation,and shorter time to ambulation and length of hospital stay compared to the control group,all with significant differences (P<0.05).Postoperative recovery time for nor-mal menstruation,vaginal bleeding,β-HCG normalization,and disappearance of intrauterine masses were significantly shor-ter in the study group than in the control group (P<0.05).The two-year recurrence rate of cesarean scar pregnancy in the stud-y group was significantly lower than that in the control group[0(0/53) vs.14.00% (7/50);x2=5.904,P=0.015].The two-year normal pregnancy rate in the study group was significantly higher than that in the control group[66.04% (35/53) vs.34.00% (17/50);x2=10.564,P=0.001].Conclusion Vaginal scar pregnancy lesion resection combined with uterine repair is highly ef-fective for treating patients with Type Ⅱ/Ⅲ CSP.It reduces intraoperative blood loss,promotes postoperative recovery,decreases the recurrence risk of cesarean scar pregnancy,and increases the rate of normal pregnancy.

关键词

阴式子宫瘢痕妊娠病灶切除/子宫修补术/瘢痕妊娠/剖宫产/临床疗效/正常妊娠

Key words

Vaginal scar pregnancy lesion resection/Uterine repair/Cesarean scar pregnancy/Cesarean section/Clinical efficacy/Normal pregnancy

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基金项目

2022年度河北省医学科学研究课题计划项目(20221493)

河北省衡水市科技计划项目(2020014042Z)

出版年

2024
保健医学研究与实践
西南大学

保健医学研究与实践

CSTPCD
影响因子:0.512
ISSN:1673-873X
参考文献量21
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