Factors influencing the efficacy of HIFU treatment for uterine fibroids
Objective To investigate the factors influencing the efficacy of high-intensity focused ultrasound (HIFU) treat-ment for uterine fibroids,providing a clinical reference for treatment.Methods A retrospective analysis was conducted on the clinical data of 102 uterine fibroid patients treated at Shangluo Central Hospital from January 2020 to December 2023.The non-perfused volume percentage (NPV%) and intraoperative ablation parameters were compared among patients with different MRI T2-weighted imaging (T2WI) signal intensities.The NPV% and intraoperative ablation parameters were also compared between patients with and without the T2-rim sign.Conditional logistic regression was used to analyze the factors influencing the immediate benefit of HIFU ablation treatment.Results The comparison of NPV% among patients with dif-ferent MRI T2WI signal intensities showed:low signal group>equal signal group>high signal group;the irradiation time and treatment dose were compared as follows:low signal group<equal signal group<high signal group,with all differences being statistically significant (P<0.05).However,no statistically significant difference was found in treatment intensity a-mong the three groups (P>0.05).Patients with the T2-rim sign had lower NPV% than those without,and higher treat-ment intensity,and treatment dose,all with statistically significant differences (P<0.05).The NPV%<75% group had longer irradiation time and higher treatment intensity than the NPV%≥75% group;medium signal intensity on T2WI was predominant,and the T2-rim sign was more common in the NPV% ≥75% group,with all differences being statistically significant (P<0.05).Logistic regression analysis showed that the factors influencing the immediate benefit of HIFU abla-tion treatment included irradiation time,treatment intensity,T2WI signal intensity,and the T2-rim sign (P<0.05).Con-clusion The T2-rim sign and T2WI signal intensity are factors influencing the immediate benefit of HIFU ablation for uter-ine fibroids.Observing preoperative MRI characteristics can provide useful information for predicting the efficacy of HIFU ablation for uterine fibroid patients.
Uterine fibroidsHigh-intensity focused ultrasoundT2WI high signal rim signNon-perfused volume