Correlation of LncRNA TINCR and FGF-1 with childhood obesity-related bronchial asthma
Objective To explore the correlation between long non-coding RNA terminal differentiation-induced non-coding RNA (LncRNA TINCR) and fibroblast growth factor-1 (FGF-1) with the severity and lung function of childhood obesity-related bronchial asthma.Methods A random sampling method was used to select 120 children with bronchial asthma trea-ted at our hospital from December 2021 to January 2023,including 60 cases of obesity-related bronchial asthma and 60 cases of non-obesity-related bronchial asthma.Additionally,120 healthy children undergoing physical examinations during the same period were selected as the control group.The children with obesity-related asthma were further assigned to the mild (29 cases),moderate (24 cases),and severe (7 cases) groups following the severity of their condition.The relative expres-sion levels of LncRNA TINCR and FGF-1,eosinophil percentage,forced expiratory volume in 1 second (FEV1),and maxi-mal mid-expiratory flow (MMEF) were measured and compared among the groups.Results Compared to the non-obesity-related asthma group and the control group,the relative expression levels of LncRNA TINCR and FGF-1 RNA were signifi-cantly higher in the obesity-related asthma group (P<0.05).Moreover,the expression levels were significantly higher in the non-obesity-related asthma group than in the control group (P<0.05).The FEV1% and MMEF of the obesity-related asthma group were significantly lower than those of the other two groups (P<0.05),and the non-obesity-related asthma group also showed significantly lower values compared to the control group (P<0.05).Within the obesity-related asthma group,the severe group had significantly higher levels of LncRNA TINCR and FGF-1 RNA than the mild and moderate groups (P<0.05).The FEV1% and MMEF in the severe and moderate groups were significantly lower than those in the mild group (P<0.05).LncRNA TINCR and FGF-1 levels in children with obesity-related asthma positively correlated with the severity of the condition (P<0.05) and negatively correlated with FEV1% and MMEF (P<0.05).LncRNA TINCR positively correlated with the percentage of eosinophils (P<0.05).Conclusion The levels of LncRNA TINCR and FGF-1 are elevated in children with obesity-related bronchial asthma and are closely correlated with the severity of the condition and lung function.
Childhood bronchial asthmaObesityLncRNA TINCRFGF-1Lung function