首页|LncRNA TINCR和FGF-1与儿童肥胖型支气管哮喘的相关性研究

LncRNA TINCR和FGF-1与儿童肥胖型支气管哮喘的相关性研究

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目的 探讨终末分化诱导的长链非编码RNA(lncRNA TINCR)和成纤维细胞生长因子-1(FGF-1)与肥胖型支气管哮喘患儿病情严重程度及肺功能的关系.方法 采用随机抽样法选取我院2021年12月—2023年1月收治的120例支气管哮喘患儿为研究对象,其中肥胖型支气管哮喘患儿60例,非肥胖型支气管哮喘患儿60例;另选取同期于我院进行健康体检的健康儿童120例作为对照组研究对象.又根据肥胖型哮喘患儿的病情严重程度分为轻度组(29例)、中度组(24例)、重度组(7例).检测所有研究对象的LncRNA TINCR和FGF-1 RNA相对表达水平、嗜酸性粒细胞百分比、第一秒用力呼气容积(FEV1)、最大呼气中段流量(MMEF)等,并分组进行比较分析.结果 与非肥胖型支气管哮喘组和对照组相比,肥胖型支气管哮喘组患儿的LncRNA TINCR和FGF-1 RNA相对表达值明显升高(P<0.05);同时,非肥胖型支气管哮喘组患儿的LncRNA TINCR和FGF-1 RNA相对表达值也高于对照组(P<0.05).肥胖型支气管哮喘组患儿的FEV1%和MMEF显著低于其他2组(P<0.05);另外,非肥胖型支气管哮喘组患儿的FEV1%和MMEF也低于对照组(P<0.05).在肥胖型支气管哮喘患儿中,重度组的LncRNA TINCR与FGF-1 RNA相对表达水平高于轻度组及中度组(P<0.05).重度组和中度组的肥胖型支气管哮喘患儿的FEV1%和MMEF都显著低于轻度组(P<0.05).肥胖型支气管哮喘患儿的LncRNA TINCR、FGF-1与病情严重程度呈正相关(P<0.05),与FEV1%和MMEF呈负相关(P<0.05).另外,LncRNA TINCR与嗜酸性粒细胞百分比呈正相关(P<0.05).结论 肥胖型支气管哮喘患儿的LncRNA TINCR和FGF-1水平较高,且与病情严重程度及肺功能密切相关.
Correlation of LncRNA TINCR and FGF-1 with childhood obesity-related bronchial asthma
Objective To explore the correlation between long non-coding RNA terminal differentiation-induced non-coding RNA (LncRNA TINCR) and fibroblast growth factor-1 (FGF-1) with the severity and lung function of childhood obesity-related bronchial asthma.Methods A random sampling method was used to select 120 children with bronchial asthma trea-ted at our hospital from December 2021 to January 2023,including 60 cases of obesity-related bronchial asthma and 60 cases of non-obesity-related bronchial asthma.Additionally,120 healthy children undergoing physical examinations during the same period were selected as the control group.The children with obesity-related asthma were further assigned to the mild (29 cases),moderate (24 cases),and severe (7 cases) groups following the severity of their condition.The relative expres-sion levels of LncRNA TINCR and FGF-1,eosinophil percentage,forced expiratory volume in 1 second (FEV1),and maxi-mal mid-expiratory flow (MMEF) were measured and compared among the groups.Results Compared to the non-obesity-related asthma group and the control group,the relative expression levels of LncRNA TINCR and FGF-1 RNA were signifi-cantly higher in the obesity-related asthma group (P<0.05).Moreover,the expression levels were significantly higher in the non-obesity-related asthma group than in the control group (P<0.05).The FEV1% and MMEF of the obesity-related asthma group were significantly lower than those of the other two groups (P<0.05),and the non-obesity-related asthma group also showed significantly lower values compared to the control group (P<0.05).Within the obesity-related asthma group,the severe group had significantly higher levels of LncRNA TINCR and FGF-1 RNA than the mild and moderate groups (P<0.05).The FEV1% and MMEF in the severe and moderate groups were significantly lower than those in the mild group (P<0.05).LncRNA TINCR and FGF-1 levels in children with obesity-related asthma positively correlated with the severity of the condition (P<0.05) and negatively correlated with FEV1% and MMEF (P<0.05).LncRNA TINCR positively correlated with the percentage of eosinophils (P<0.05).Conclusion The levels of LncRNA TINCR and FGF-1 are elevated in children with obesity-related bronchial asthma and are closely correlated with the severity of the condition and lung function.

Childhood bronchial asthmaObesityLncRNA TINCRFGF-1Lung function

冯涛、任海玉、吴雅婷、景燕平、王琴、曹燕玲

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河北张家口市妇幼保健院儿科,河北张家口 075000

河北北方学院附属第一医院儿内科,河北张家口 075000

小儿支气管哮喘 肥胖 终末分化诱导的长链非编码RNA 成纤维细胞生长因子-1 肺功能

河北省医学科学研究课题

20232077

2024

保健医学研究与实践
西南大学

保健医学研究与实践

CSTPCD
影响因子:0.512
ISSN:1673-873X
年,卷(期):2024.21(4)
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