首页|PCT、CRP及IL-10水平与IIP急性加重期患者预后的相关性分析

PCT、CRP及IL-10水平与IIP急性加重期患者预后的相关性分析

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目的 探讨降钙素原(PCT)、C-反应蛋白(CRP)以及白细胞介素10(IL-10)水平与特发性间质性肺炎(IIP)急性加重期患者预后的相关性,以期为临床治疗提供参考.方法 选取2020年9月—2023年6月于西昌市人民医院进行治疗的110例IIP患者及同期于本院进行体检的45例健康者(对照组)作为研究对象.根据IIP分期标准将110例IIP患者分为急性加重期组57例与临床稳定期组53例.比较急性加重期组、临床稳定期组、对照组患者PCT、CRP及IL-10水平.根据IIP急性加重期患者预后情况分为预后生存组(n=50)和预后死亡组(n=7),分别进行影响IIP急性加重期患者预后的单因素分析及多因素Logistic回归分析.使用Pearson线性相关分析PCT、CRP及IL-10水平与IIP急性加重期患者红细胞沉降率(ESR)的相关性.结果 急性加重期组、临床稳定期组患者PCT、CRP及IL-10水平均高于对照组研究对象,差异均有统计学意义(P<0.05).2组患者ESR、PCT、CRP及IL-10水平比较,差异均有统计学意义(P<0.05).经多因素Logistic回归分析可知,ESR、PCT、CRP及IL-10水平是影响IIP急性加重期患者预后的影响因素(P<0.05).经Pearson线性相关分析,血清PCT、CRP及IL-10与IIP急性加重期患者ESR呈正相关,差异有统计学意义(P<0.05).结论 PCT、CRP及IL-10水平与IIP急性加重期患者病情发展存在相关性,三者水平会随着IIP病情的加重而升高,且可作为IIP急性加重期患者的预后评估指标,具有临床指导意义.
Correlation analysis of PCT,CRP,and IL-10 levels with prognosis in patients with acute exacerbation of idiopathic interstitial pneumonia
Objective To investigate the correlation between levels of procalcitonin (PCT),C-reactive protein (CRP),and interleukin-10 (IL-10) and the prognosis in patients with acute exacerbation of idiopathic interstitial pneumonia (IIP),ai-ming to provide evidence for clinical treatment.Methods A total of 110 patients with IIP treated at the Xichang People's Hospital from September 2020 to June 2023 were selected for the study.Simultaneously,45 healthy individuals undergoing physical examinations at the hospital served as the control group.According to the staging criteria of IIP,the 110 patients were allocated to an acute exacerbation group (n=57) and a clinically stable group (n=53).Levels of PCT,CRP,and IL-10 were compared among the acute exacerbation group,the clinically stable group,and the control group.Based on the prognosis of patients in the acute exacerbation group,they were further assigned to a survival group (n=50) and a death group (n=7).Univariate analysis and multivariate logistic regression analysis were performed to identify factors influencing prognosis in patients with acute exacerbation of IIP.Pearson correlation analysis was used to assess the correlation between PCT,CRP,and IL-10 levels and erythrocyte sedimentation rate (ESR) in these patients.Results Levels of PCT,CRP,and IL-10 in the acute exacerbation and clinically stable groups were significantly higher than those in the control group (P<0.05).Significant differences in ESR,PCT,CRP,and IL-10 levels were observed between the two patient groups (P<0.05).Multivariate logistic regression analysis indicated that ESR,PCT,CRP,and IL-10 levels were influencing factors for prognosis in patients with acute exacerbation of IIP (P<0.05).Pearson correlation analysis demonstrated that serum PCT,CRP,and IL-10 levels were positively correlated with ESR in these patients,with statistical significance (P<0.05).Con-clusion PCT,CRP,and IL-10 levels are correlated with disease progression in patients with acute exacerbation of IIP.Their levels increase with the severity of IIP and can serve as prognostic indicators,providing clinical guidance.

PCTCRPIL-10Idiopathic interstitial pneumoniaDisease progressionPrognosisCorrelation

肖莲春、毛光建、王友丽、吴旭、张莹

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四川省西昌市人民医院呼吸与危重症医学科,四川西昌 615000

西昌学院附属医院/西昌市人民医院呼吸与危重症医学科,四川西昌 615000

PCT CRP IL-10 特发性间质性肺炎 病情 预后 相关性

四川省科技计划项目

22YJC1523

2024

保健医学研究与实践
西南大学

保健医学研究与实践

CSTPCD
影响因子:0.512
ISSN:1673-873X
年,卷(期):2024.21(4)
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