Correlation analysis of PCT,CRP,and IL-10 levels with prognosis in patients with acute exacerbation of idiopathic interstitial pneumonia
Objective To investigate the correlation between levels of procalcitonin (PCT),C-reactive protein (CRP),and interleukin-10 (IL-10) and the prognosis in patients with acute exacerbation of idiopathic interstitial pneumonia (IIP),ai-ming to provide evidence for clinical treatment.Methods A total of 110 patients with IIP treated at the Xichang People's Hospital from September 2020 to June 2023 were selected for the study.Simultaneously,45 healthy individuals undergoing physical examinations at the hospital served as the control group.According to the staging criteria of IIP,the 110 patients were allocated to an acute exacerbation group (n=57) and a clinically stable group (n=53).Levels of PCT,CRP,and IL-10 were compared among the acute exacerbation group,the clinically stable group,and the control group.Based on the prognosis of patients in the acute exacerbation group,they were further assigned to a survival group (n=50) and a death group (n=7).Univariate analysis and multivariate logistic regression analysis were performed to identify factors influencing prognosis in patients with acute exacerbation of IIP.Pearson correlation analysis was used to assess the correlation between PCT,CRP,and IL-10 levels and erythrocyte sedimentation rate (ESR) in these patients.Results Levels of PCT,CRP,and IL-10 in the acute exacerbation and clinically stable groups were significantly higher than those in the control group (P<0.05).Significant differences in ESR,PCT,CRP,and IL-10 levels were observed between the two patient groups (P<0.05).Multivariate logistic regression analysis indicated that ESR,PCT,CRP,and IL-10 levels were influencing factors for prognosis in patients with acute exacerbation of IIP (P<0.05).Pearson correlation analysis demonstrated that serum PCT,CRP,and IL-10 levels were positively correlated with ESR in these patients,with statistical significance (P<0.05).Con-clusion PCT,CRP,and IL-10 levels are correlated with disease progression in patients with acute exacerbation of IIP.Their levels increase with the severity of IIP and can serve as prognostic indicators,providing clinical guidance.