Relationship between islet cell autoantibodies,anti-glutamic acid decarboxylase antibodies,and diabetic microangiopathy in Patient with type 2 diabetes
Objective To investigate the relationship between islet-cell antibodies(ICA),insulin autoantibodies(IAA),and glutamic acid decarboxylase antibodies(GADA)with diabetic microangiopathy(DMAP)in Patient with type 2 diabetes mel-litus(T2DM).Methods A retrospective analysis was conducted on the clinical data of 114 T2DM patients admitted to our hospital from November 2023 to March 2024.Patients were assigned to two groups based on the occurrence of DMAP:the simple T2DM group(n=61)and the complication group(n=53).The levels of IAA,ICA,and GADA were detected upon admission for all patients.The receiver operating characteristic(ROC)curve analysis was used to assess the value of IAA,ICA,and GADA in evaluating DMAP,and multivariate logistic regression analysis was adopted to explore the influencing factors of DMAP.Results The levels of ICA,IAA,and GADA in the complication group were all higher than those in the simple T2DM group,with statistically significant differences(P<0.05).The areas under the curve(AUC)for ICA,IAA,and GADA in evaluating DMAP in T2DM patients were 0.792,0.736,and 0.805,respectively,and the AUC for combined detection was 0.912.The proportion of T2DM patients with a disease course of ≥8 years and a history of alcohol consump-tion in the complication group was significantly higher than that in the simple T2DM group(P<0.05).Logistic regression results showed that a T2DM disease course of ≥8 years(OR=2.314,95%CI:1.136-4.714),ICA≥4 183.62 RU/mL(OR=4.221,95%CI:1.849-9.633),IAA≥5 587.37 RU/mL(OR=3.449,95%CI:1.654-7.192),and GADA≥3 667.92 IU/mL(OR=5.150,95%CI:2.058-12.888)are risk factors for DMAP in T2DM patients(P<0.05).Con-clusion ICA,IAA,and GADA are closely related to the occurrence of DMAP in T2DM patients,and combined detection is helpful for the assessment of DMAP.