Clinical efficacy of 694 nm Q-switched ruby fractional laser combined with topical tranexamic acid injection for the treatment of melasma
Objective To explore the clinical efficacy of 694 nm Q-switched ruby fractional laser combined with topical tranexamic acid injection for the treatment of melasma,providing a reference for its clinical treatment.Methods A total of 106 melasma patients treated at XD Group Hospital from July 2019 to March 2023 were selected as research participants and divided into a control group(52 cases)and an observation group(54 cases)based on different treatment plans.The control group patients were treated with 694 nm Q-switched ruby fractional laser,while the observation group patients with 694 nm Q-switched ruby fractional laser combined with topical tranexamic acid injection.The clinical efficacy,melasma area and se-verity index(MASI)scores,skin conditions,recurrence rates,and adverse reaction occurrence between the two groups were compared before and after treatment.Results The overall response rate of treatment in the observation group was 83.33%(45/54),which was higher than that in the control group at 63.46%(33/52),with a statistically difference(X2=5.382,P=0.020).No statistically significant difference was observed in MASI scores between the two groups before treatment(P>0.05);after treatment,the MASI scores in both groups were significant lower than before treatment,and the observa-tion group had significant lower scores than the control group(P<0.05).No statistically significant differences were noted in the skin condition scores of skin pores,texture,wrinkles,and pigmented spots between the two groups before treatment(P>0.05).The skin condition scores in all four categories in both groups were significantly decreased after treatment,and the observation group had significantly lower scores than the control group(P<0.05).The recurrence rate of melasma in the observation group was 5.56%(3/54),which was lower than that in the control group at 19.23%(10/52),with a sta-tistically significant difference(X2=4.604,P=0.032).The incidence of adverse reactions in the control and observation groups was 9.62%(5/52)and 7.41%(4/54),respectively,with no statistically significant difference(X2=0.004,P=0.953).Conclusion The treatment of melasma patients with 694 nm Q-switched ruby fractional laser combined with topical tranexamic acid injection is effective,can significantly improve patients'skin pigmentation symptoms,and has a lower risk of adverse reactions and recurrence.