首页|694 nm调Q红宝石点阵激光联合氨甲环酸注射液外敷治疗黄褐斑的临床疗效

694 nm调Q红宝石点阵激光联合氨甲环酸注射液外敷治疗黄褐斑的临床疗效

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目的 探讨694 nm调Q红宝石点阵激光联合氨甲环酸注射液外敷治疗黄褐斑的临床疗效,以期为临床治疗黄褐斑提供参考.方法 选取2019年7月-2023年3月西电集团医院收治的106例黄褐斑患者为研究对象,根据治疗方案不同分为对照组(52例)和观察组(54例).对照组患者采用694 nm调Q红宝石点阵激光治疗,观察组患者采用694 nm调Q红宝石点阵激光联合氨甲环酸注射液外敷治疗.比较2组患者的临床疗效,治疗前后黄褐斑面积和严重程度指数(MASI)评分、皮肤状态、复发率及不良反应发生情况.结果 观察组患者的治疗总有效率为83.33%(45/54),高于对照组的63.46%(33/52),差异有统计学意义(x2=5.382,P=0.020).2组患者治疗前MASI评分比较,差异无统计学意义(P>0.05);2组患者治疗后MASI评分均低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05).2组患者治疗前皮肤毛孔、纹理、皱纹、色素斑4项皮肤状态评分比较,差异均无统计学意义(P>0.05);2组患者治疗后皮肤毛孔、皱纹、纹理、色素斑4项皮肤状态评分均低于治疗前,且观察组均低于对照组,差异均有统计学意义(P<0.05).观察组患者黄褐斑复发率为5.56%(3/54),低于对照组的19.23%(10/52),差异有统计学意义(X2=4.604,P=0.032).对照组和观察组患者不良反应发生率分别为9.62%(5/52)和7.41%(4/54),差异无统计学意义(x2=0.004,P=0.953).结论 黄褐斑患者采用694 nm调Q红宝石点阵激光联合氨甲环酸注射液外敷治疗效果较好,可有效改善患者皮肤色素沉着症状,且不良反应发生风险及复发风险均较低.
Clinical efficacy of 694 nm Q-switched ruby fractional laser combined with topical tranexamic acid injection for the treatment of melasma
Objective To explore the clinical efficacy of 694 nm Q-switched ruby fractional laser combined with topical tranexamic acid injection for the treatment of melasma,providing a reference for its clinical treatment.Methods A total of 106 melasma patients treated at XD Group Hospital from July 2019 to March 2023 were selected as research participants and divided into a control group(52 cases)and an observation group(54 cases)based on different treatment plans.The control group patients were treated with 694 nm Q-switched ruby fractional laser,while the observation group patients with 694 nm Q-switched ruby fractional laser combined with topical tranexamic acid injection.The clinical efficacy,melasma area and se-verity index(MASI)scores,skin conditions,recurrence rates,and adverse reaction occurrence between the two groups were compared before and after treatment.Results The overall response rate of treatment in the observation group was 83.33%(45/54),which was higher than that in the control group at 63.46%(33/52),with a statistically difference(X2=5.382,P=0.020).No statistically significant difference was observed in MASI scores between the two groups before treatment(P>0.05);after treatment,the MASI scores in both groups were significant lower than before treatment,and the observa-tion group had significant lower scores than the control group(P<0.05).No statistically significant differences were noted in the skin condition scores of skin pores,texture,wrinkles,and pigmented spots between the two groups before treatment(P>0.05).The skin condition scores in all four categories in both groups were significantly decreased after treatment,and the observation group had significantly lower scores than the control group(P<0.05).The recurrence rate of melasma in the observation group was 5.56%(3/54),which was lower than that in the control group at 19.23%(10/52),with a sta-tistically significant difference(X2=4.604,P=0.032).The incidence of adverse reactions in the control and observation groups was 9.62%(5/52)and 7.41%(4/54),respectively,with no statistically significant difference(X2=0.004,P=0.953).Conclusion The treatment of melasma patients with 694 nm Q-switched ruby fractional laser combined with topical tranexamic acid injection is effective,can significantly improve patients'skin pigmentation symptoms,and has a lower risk of adverse reactions and recurrence.

694 nm Q-switched ruby fractional laserTranexamic acid injectionMelasmaClinical efficacySkin conditionRecurrence risk

李林丽、刘平、苏慧、王雨婷、袁仪珮

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西电集团医院皮肤科,西安 710077

西安交通大学第二附属医院皮肤科,西安 710004

694 nm调Q红宝石点阵激光 氨甲环酸注射液 黄褐斑 临床疗效 皮肤状态 复发风险

陕西省社会发展科技攻关项目

2023SF-124

2024

保健医学研究与实践
西南大学

保健医学研究与实践

CSTPCD
影响因子:0.512
ISSN:1673-873X
年,卷(期):2024.21(5)
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