Clinical study on the treatment of postherpetic neuralgia with high-voltage pulsed radiofrequency combined with ozone autohemotherapy
Objective To explore the clinical efficacy of high-voltage pulsed radiofrequency combined with ozone autohemo-therapy(O3-AHT)in the treatment of postherpetic neuralgia(PHN),to provide a reference for the treatment of PHN.Methods A total of 90 PHN patients hospitalized for treatment from May 2021 to August 2022 were selected and randomly assigned to an observation group and a control group,each consisting of 45 cases,using computer-generated random num-bers.The control group patients received high-voltage pulsed radiofrequency,while the observation group patients received high-voltage pulsed radiofrequency combined with O3-AHT.The clinical efficacy of the two groups was compared,as well as the visual analog scale(VAS)scores,sleep quality,and levels of tumor necrosis factor-alpha(TNF-α)and interleukin-6(IL-6)before and after treatment.Results The overall response rate of treatment in the observation group was 95.56%(43/45),which was higher than the 80.00%(36/45)in the control group,and the difference was statistically significant(x2=5.075,P=0.024).No statistically significant difference was observed in VAS scores between the two groups before treatment(P>0.05);after treatment,the VAS scores at all time points in both groups were significantly lower than before treatment,and the observation group was lower than the control group at the same time points(P<0.05).There was no statistically significant difference in the Pittsburgh Sleep Quality Index(PSQI)scores between the two groups before treat-ment(P>0.05);after treatment,the PSQI scores at all time points in both groups were significantly lower than before treatment,and the observation group was significantly lower than the control group at the same time points(P<0.05).No statistically significant difference was observed in IL-6 and TNF-α levels between the two groups before treatment(P>0.05).After treatment,the levels of IL-6 and TNF-α in both groups were significantly lower than before treatment,and the observation group was significantly lower than the control group(P<0.05).No complications such as pneumothorax or nerve injury occurred in either group during the treatment period.Conclusion The combination of high-voltage pulsed radio-frequency and O3-AHT is conducive to reducing the pain level of PHN patients,improving sleep quality,and lowering the levels of inflammatory factors,holding promise for a wider application in clinical practice.