首页|高电压脉冲射频联合三氧自体血回输疗法治疗带状疱疹后神经痛的临床研究

高电压脉冲射频联合三氧自体血回输疗法治疗带状疱疹后神经痛的临床研究

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目的 探讨高电压脉冲射频联合三氧自体血回输疗法(O3-AHT)治疗带状疱疹后神经痛(PHN)的临床效果,以期为PHN的治疗提供参考.方法 选取2021年5月-2022年8月住院治疗的90例PHN患者,采用计算机生成的随机数分为观察组和对照组,每组45例.对照组患者采用高电压脉冲射频治疗,观察组患者采用高电压脉冲射频联合O3-AHT进行治疗,比较2组患者的临床疗效,治疗前后视觉模拟评分法(VAS)评分、睡眠质量及肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平.结果 观察组患者的治疗总有效率为95.56%(43/45),高于对照组的80.00%(36/45),差异有统计学意义(x2=5.075,P=0.024).2组患者治疗前VAS评分比较,差异无统计学意义(P>0.05);2组患者治疗后各时间点VAS评分均低于治疗前,且相同时间点观察组均低于对照组,差异均有统计学意义(P<0.05).2组患者治疗前匹滋堡睡眠质量指数问卷(PSQI)评分比较,差异无统计学意义(P>0.05);2组患者治疗后各时间点PSQI评分均低于治疗前,且相同时间点观察组均低于对照组,差异均有统计学意义(P<0.05).2组患者治疗前IL-6及TNF-α水平比较,差异无统计学意义(P>0.05);2组患者治疗后IL-6及TNF-α水平均低于治疗前,且观察组均低于对照组,差异均有统计学意义(P<0.05).2组患者治疗期间均未发生气胸、神经损伤等并发症.结论 高电压脉冲射频联合O3-AHT有助于减轻PHN患者的疼痛程度,提高患者的睡眠质量,且能降低炎症因子水平,值得在临床上推广应用.
Clinical study on the treatment of postherpetic neuralgia with high-voltage pulsed radiofrequency combined with ozone autohemotherapy
Objective To explore the clinical efficacy of high-voltage pulsed radiofrequency combined with ozone autohemo-therapy(O3-AHT)in the treatment of postherpetic neuralgia(PHN),to provide a reference for the treatment of PHN.Methods A total of 90 PHN patients hospitalized for treatment from May 2021 to August 2022 were selected and randomly assigned to an observation group and a control group,each consisting of 45 cases,using computer-generated random num-bers.The control group patients received high-voltage pulsed radiofrequency,while the observation group patients received high-voltage pulsed radiofrequency combined with O3-AHT.The clinical efficacy of the two groups was compared,as well as the visual analog scale(VAS)scores,sleep quality,and levels of tumor necrosis factor-alpha(TNF-α)and interleukin-6(IL-6)before and after treatment.Results The overall response rate of treatment in the observation group was 95.56%(43/45),which was higher than the 80.00%(36/45)in the control group,and the difference was statistically significant(x2=5.075,P=0.024).No statistically significant difference was observed in VAS scores between the two groups before treatment(P>0.05);after treatment,the VAS scores at all time points in both groups were significantly lower than before treatment,and the observation group was lower than the control group at the same time points(P<0.05).There was no statistically significant difference in the Pittsburgh Sleep Quality Index(PSQI)scores between the two groups before treat-ment(P>0.05);after treatment,the PSQI scores at all time points in both groups were significantly lower than before treatment,and the observation group was significantly lower than the control group at the same time points(P<0.05).No statistically significant difference was observed in IL-6 and TNF-α levels between the two groups before treatment(P>0.05).After treatment,the levels of IL-6 and TNF-α in both groups were significantly lower than before treatment,and the observation group was significantly lower than the control group(P<0.05).No complications such as pneumothorax or nerve injury occurred in either group during the treatment period.Conclusion The combination of high-voltage pulsed radio-frequency and O3-AHT is conducive to reducing the pain level of PHN patients,improving sleep quality,and lowering the levels of inflammatory factors,holding promise for a wider application in clinical practice.

High-voltage pulsed radiofrequencyOzone autohemotherapyPostherpetic neuralgiaSleep qualityInflamma-tory response

陈吉祥、李玉琴、移琪霞、袁涛、谢朝晖

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兰州大学第一医院疼痛科,兰州 730000

高电压脉冲射频 三氧自体血回输疗法 带状疱疹后神经痛 睡眠质量 炎症反应

甘肃省科技计划项目-青年科技基金

21JR1RA109

2024

保健医学研究与实践
西南大学

保健医学研究与实践

CSTPCD
影响因子:0.512
ISSN:1673-873X
年,卷(期):2024.21(5)
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