Expression and clinical significance of IgE,IgA,and MMP-13 in children with recurrent henoch-sch?nlein purpura
Objective To investigate the expression levels of immunoglobulin E(IgE),immunoglobulin A(IgA),and matrix metalloproteinase-13(MMP-13)in the serum of children with recurrent Henoch-Schönlein purpura(HSP)and their clinical significance,aiming to provide a reference for clinical treatment.Methods A total of 161 children with HSP admitted to the Second Affiliated Hospital of Air Force Medical University from March 2020 to January 2023 were selected as the observa-tion group,and 143 healthy children who underwent physical examination during the same period were selected as controls.Fasting venous blood of 5 mL was drawn from the children in the observation group on the morning after admission,and from the participants in the control group on the morning of the physical examination.The levels of serum IgE,IgA,and MMP-13 in different populations were compared,and the recurrence of HSP in the observation group during the follow-up process was analyzed.The univariate factors affecting the recurrence of HSP were analyzed,and multivariate logistic regres-sion analysis was used to assess the multiple factors influencing the recurrence of HSP.ResultsThe levels of IgE,IgA,and MMP-13 in the observation group were significantly higher than those in the control group(P<0.05).After a 12-month follow-up,36 out of 161 HSP children recurred(22.36%),with 15 experiencing joint pain again,10 abdominal pain,7 joint effusion,and 4 other clinical symptoms,all of which were classified as the recurrence group.During the follow-up period,125 out of 161 HSP children(77.64%)did not demonstrate clinical symptoms and were classified as the non-recurrence group.The proportion of dietary control and platelet count in the recurrence group were lower than those in the non-recur-rence group,and the levels of lactate dehydrogenase,IgE,IgA,and MMP-13 were higher than those in the non-recurrence group,with all differences being statistically significant(P<0.05).Multivariate logistic regression analysis results showed that lack of dietary control,reduced platelet count,elevated lactate dehydrogenase level,increased IgE level,increased IgA level,and increased MMP-13 level were risk factors influencing the prognosis and recurrence of HSP(P<0.05).Conclusion In children with recurrent HSP,the levels of IgE,IgA,and MMP-13 all show an increasing trend,and all three,along with lack of dietary control,reduced platelet count,and elevated lactate dehydrogenase level,are considered risk factors for HSP recurrence.