Clinical manifestations and related influencing factors of adverse drug reactions to Semaglutide
Objective To analyze the clinical manifestations and related influencing factors of adverse drug reactions(ADRs)to semaglutide,providing references for clinical treatment.Methods Clinical data from 597 patients treated with semaglu-tide at the Endocrinology Department of Chongqing Ninth People's Hospital from January 2022 to December 2023 were col-lected.Patients were assigned to two groups based on the occurrence of ADRs:the reaction group(n=177)and the non-re-action group(n=420).Data on patient's name,age,gender,body mass index(BMI),purpose of medication,semaglutide maintenance dose,and follow-up details or telephone calls were collected.Any discomfort post-medication was recorded thoroughly through outpatient or telephone follow-ups.Results The most common organ/system affected by semaglutide ADRs was the digestive system,accounting for 82.48％of cases.Among the 177 patients with ADRs,18 patients(10.16％)discontinued the drug due to intolerable ADRs,7 patients(3.95％)required hospitalization due to persistent ADR-related symptoms,and 2 patients(1.12％)died due to exacerbation of underlying diseases triggered by severe diarrhe-a.Significant differences between the two groups were observed in BMI levels,off-label drug use,and purpose of medication(P＜0.05).Multivariate logistic regression analysis revealed that low BMI,type 2 diabetes,and off-label drug use were factors influencing the occurrence of ADRs to semaglutide(P＜0.05).Conclusion Gastrointestinal ADRs are common with semaglutide,and it may also increase the risk of gallstone formation.It is recommended that semaglutide be used strictly ac-cording to indications,with an evaluation of the patient's digestive system and thyroid status before administration,and close monitoring of early and long-term ADRs during treatment.
SemaglutideAdverse drug reactionsClinical manifestationsInfluencing factors
万方数据
维普
