Mean platelet volume/platelet count ratio for predicting deep vein thrombosis after cesarean section in preeclamptic patients
Objective To explore the predictive value of the mean platelet volume/platelet count(MPV/PLT)ratio for deep vein thrombosis(DVT)after cesarean section in preeclamptic(PE)patients,aiming to provide a reference for clinical deci-sion-making.Methods One hundred and three PE patients who underwent cesarean section at a hospital in Hebei Province from May 2020 to April 2023 were selected as the study participants.Clinical data of the participants were collected.They were assigned to two groups based on the presence or absence of DVT postoperatively:the DVT group(n=22)and the non-DVT group(n=81).The mean platelet volume(MPV),platelet count(PLT),and MPV/PLT level in the peripheral blood of the two groups were compared.The predictive value of peripheral blood MPV,PLT,and MPV/PLT level for DVT in PE patients after cesarean section was assessed using the receiver operating characteristic(ROC)curve.Moreover,a multifactorial logistic regression analysis was conducted to explore the influencing factors of DVT occurrence in PE patients after cesarean section.Results The levels of peripheral blood MPV and MPV/PLT in the DVT group were significantly higher compared to the non-DVT group,while the PLT level was significantly lower in the DVT group(P＜0.05).The ROC curve showed that the areas under the curve(AUC)for predicting DVT in PE patients after cesarean section for pe-ripheral blood MPV,PLT,and MPV/PLT were 0.851(0.799-0.903),0.744(0.692-0.796),and 0.902(0.850-0.954),respectively.The cutoff values were 11.43 fL,144.65 × 109/L,and 0.11,with specificities of 66.59％,54.23％,and 85.91％,and sensitivities of 90.08％,90.08％,and 83.44％,respectively.The proportion of patients in the DVT group with a pre-pregnancy body mass index(BMI)≥30 kg/m2 and puerperal bed rest time ≥3 days was higher than that in the non-DVT group,and the levels of D-dimer and fibrinogen were higher than those in the non-DVT group,with statisti-cally significant differences(P＜0.05).Multifactorial analysis indicated that a pre-pregnancy BMI ≥30 kg/m2(OR=2.277,95％CI:1.554-3.337),puerperal bed rest time ≥3 days(OR=1.950,95％CI:1.379-2.759),elevated fibrino-gen levels(OR=2.726,95％CI:1.775-4.188),and MPV/PLT ≥0.11(OR=3.083,95％CI:1.961-4.849)are inde-pendent risk factors for DVT occurrence in PE patients after cesarean section(P＜0.05).Conclusion Elevated MPV/PLT levels in PE patients are closely correlated with the occurrence of DVT after cesarean section and can serve as a potential marker for predicting DVT in these patients after cesarean section,which is worth promoting in clinical practice.
Mean platelet volume/platelet count ratioPreeclampsiaCesarean sectionDeep vein thrombosis
万方数据
维普
