Analysis of influencing factors of enteral nutrition-associated diarrhea in patients with severe craniocerebral injury based on lasso regression
Objective To explore the factors affecting enteral nutrition-associated diarrhea in patients with severe craniocere-bral injury,providing a theoretical basis for reducing the incidence of enteral nutrition-associated diarrhea.Methods A total of 262 patients with severe craniocerebral injury who underwent enteral nutrition treatment from January 2022 to May 2024 at a grade A tertiary hospital in Chongqing were selected as the study participants,who were assigned to diarrhea group(n=102)and non-diarrhea group(n=160)based on the occurrence of enteral nutrition-associated diarrhea.Univariate analysis and Lasso regression were used to screen influencing factors.Moreover,binary logistic regression analysis was conducted to deter-mine the independent influencing factors for enteral nutrition-associated diarrhea in patients with severe craniocerebral injury.Results Differences in Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)scores,length of ICU stay,fasting duration,use or non-use of mechanical ventilation,presence or absence of infection,types of antibiotics used,duration of antibiotic use,use or non-use of proton pump inhibitors,use or non-use of gastrointestinal prokinetic drugs,use or non-use of oral potassium preparations,use or non-use of vasoactive drugs,types of vasoactive drugs used,and albumin levels at admission and before enteral nutrition in the two groups were statistically significant(P＜0.05).APACHE Ⅱ score(OR=1.117,95％CI:1.040-1.199),mechanical ventilation(OR=2.695,95％CI:1.064-6.827),number of antibiotic types(OR=1.888,95％CI:1.333-2.673),use of gastrointestinal prokinetic drugs(OR=2.620,95％CI:1.222-5.620),and albumin levels before enteral nutrition(OR=0.883,95％CI:0.812-0.960)were independent influencing factors for enteral nutrition-associated diarrhea in patients with severe cranio-cerebral injury.Conclusion The incidence of enteral nutrition-associated diarrhea in patients with severe craniocerebral injury remains relatively high.Clinically,measures should be taken for patients with high APACHE Ⅱ scores,those on mechanical ventilation,those using gastrointestinal prokinetic drugs,and those using multiple types of antibiotics to reduce the inci-dence of enteral nutrition-associated diarrhea.
Severe craniocerebral injuryEnteral nutrition-associated diarrheaRisk factors
万方数据
维普
