首页|抗蠕形螨治疗对伴发玫瑰痤疮的慢性自发性荨麻疹临床疗效的回顾性分析

抗蠕形螨治疗对伴发玫瑰痤疮的慢性自发性荨麻疹临床疗效的回顾性分析

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目的 评估奥硝唑抗蠕形螨治疗对伴发玫瑰痤疮的慢性自发性荨麻疹的临床疗效,以期为临床决策的制定提供参考.方法 回顾分析2014年2月—2023年2月在中国人民解放军联勤保障部队第940医院皮肤科门诊接受奥硝唑抗蠕形螨治疗的124例伴发蠕形螨阳性玫瑰痤疮的慢性自发性荨麻疹患者的临床资料.通过对比治疗前,抗蠕形螨治疗4周、8周、12周后的7日荨麻疹活动度(UAS7)评分、玫瑰痤疮临床评分、症状积分下降指数(SSRI)评估疾病的治疗效果.结果 重复测量方差分析结果显示,不同时间点患者的UAS7评分和玫瑰痤疮临床评分差异均有统计学意义(P<0.05).治疗第4周、第8周、第12周,患者的慢性自发性荨麻疹临床疗效总有效率分别为78.23%、80.65%、91.13%,玫瑰痤疮临床疗效总有效率分别为91.13%、94.35%、92.74%.趋势卡方检验结果显示,随着观察时间的延长,患者慢性自发性荨麻疹的治疗总有效率呈逐步上升趋势(χ2趋势=7.412,P<0.05);玫瑰痤疮的治疗总有效率则没有发现这种趋势(χ2趋势=0.239,P>0.05).相关分析结果显示,患者UAS7评分与临床观察时间呈负相关(rs=-0.727,P<0.05),玫瑰痤疮临床评分与临床观察时间呈负相关(rs=-0.584,P<0.05).结论 奥硝唑抗蠕形螨治疗对慢性自发性荨麻疹可能有效,人蠕形螨感染或与慢性自发性荨麻疹有关.
Retrospective analysis of the clinical efficacy of anti-Demodex treatment in chronic spontaneous urticaria with rosacea
Objective To evaluate the clinical efficacy of ornidazole anti-Demodex treatment in chronic spontaneous urticaria with rosacea,aiming to provide a reference for clinical decision-making.Methods A retrospective analysis was conducted on the clinical data of 124 patients with chronic spontaneous urticaria and rosacea positive for Demodex,who were treated with ornidazole anti-Demodex treatment at the Outpatient Department of Dermatology of the 940 th Hospital of Joint Logistic Support Force of PLA from February 2014 to February 2023.The therapeutic effects were assessed by comparing the 7-day urticaria activity score(UAS7),rosacea clinical score,and symptom score reduction index(SSRI)before treatment and af-ter 4 weeks,8 weeks,and 12 weeks of anti-Demodex treatment.Results The results of repeated measures ANOVA showed statistically significant differences in UAS7 and rosacea clinical scores at different time points(P<0.05).At the 4 th,8 th,and 12 th weeks of treatment,the overall response rates of clinical efficacy for chronic spontaneous urticaria were 78.23%,80.65%,and 91.13%,respectively,and the overall response rates of clinical efficacy for rosacea were 91.13%,94.35%,and 92.74%,respectively.The trend chi-square test results indicated that with the increase of observation time,the overall response rate of treatment for chronic spontaneous urticaria demonstrated a gradual upward trend(χ2trend=7.412,P<0.05);no such trend was found for the treatment of rosacea(χ2trend=0.239,P>0.05).The correlation analysis results showed that the UAS7 score was negatively correlated with the clinical observation time(rs=-0.727,P<0.05),and the rosacea clinical score was negatively correlated with the clinical observation time(rs=-0.584,P<0.05).Conclusion Ornidazole anti-Demodex treatment may be effective for chronic spontaneous urticaria,and Demodex infection may be asso-ciated with chronic spontaneous urticaria.

DemodexChronic spontaneous urticariaRosacea

但娜、王竹君、李家铖、周家衍、毕盈盈、周楠、栾秀丽、罗洋

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兰州大学第二临床医学院,兰州 730030

中国人民解放军联勤保障部队第940医院皮肤科,兰州 730050

西北民族大学医学部,兰州 730030

蠕形螨 慢性自发性荨麻疹 玫瑰痤疮

2024

保健医学研究与实践
西南大学

保健医学研究与实践

CSTPCD
影响因子:0.512
ISSN:1673-873X
年,卷(期):2024.21(10)