Analysis of the impact of folic acid metabolism gene polymorphism-guided folic acid supplementation during pregnancy on the incidence of birth defects in newborns
Objective To explore the impact of folic acid supplementation during pregnancy guided by folic acid gene poly-morphism detection results on the incidence of birth defects in newborns,aiming to provide a reference for the development of individualized folic acid supplementation plans during pregnancy clinically.Methods Clinical data of 216 pregnant women(study participants)who were registered,underwent regular prenatal check-ups,and delivered at a hospital in Sichuan Prov-ince from August 2021 to August 2022 were retrospectively collected.The study participants were allocated to a control group(110 cases)and an observation group(106 cases)based on the folic acid supplementation plan.The control group re-ceived routine folic acid supplementation,while the observation group,folic acid supplementation based on the results of gene polymorphism detection.The clinical characteristics of the newborns,the incidence of birth defects,and the incidence of anemia in pregnant women were compared between the two groups.Additionally,the changes in folic acid and homocys-teine(Hcy)levels in pregnant women of the observation group before and after folic acid supplementation based on gene pol-ymorphism detection results were explored.Results The birth length,head circumference,and body weight of newborns in the observation group were significantly better than those in the control group(P<0.05).However,no significant differ-ence was noted in the incidence of preterm birth between the two groups(P>0.05).The incidence of birth defects in new-borns of the observation group was significantly lower than that in the control group(0.94%vs.7.27%;P<0.05).The overall incidence of anemia in the observation group was significantly lower than that in the control group(31.13%vs.48.18%;P<0.05).After three months of folic acid supplementation,the folic acid levels of pregnant women in the obser-vation group with different risk levels increased significantly,and the Hcy levels decreased significantly(P<0.05).Conclu-sion Folic acid supplementation during pregnancy guided by folic acid metabolism gene polymorphism is beneficial for re-ducing the risk of anemia during pregnancy,facilitating the control of folic acid and Hcy levels,and preventing the occur-rence of birth defects in newborns.
万方数据
维普
