Objective To investigate the short-term efficacy of single-port thoracoscopic lobectomy in elderly patients with non-small cell lung cancer(NSCLC)and its impact on the antigen levels of serum squamous cell carcinoma(SCC),aiming to provide a reference for clinical treatment.Methods A total of 186 elderly NSCLC patients admitted to the Cangzhou Cen-tral Hospital from June 2020 to June 2023 were selected as the study participants.Patients were assigned to a single-port group(underwent single-port thoracoscopic lobectomy,n=62),a two-port group(underwent two-port thoracoscopic lobec-tomy,n=62),and a three-port group(underwent three-port thoracoscopic lobectomy,n=62)using a random number ta-ble method.The perioperative indicators,postoperative pain numerical rating scale(NRS)scores,pulmonary function indi-cators[forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC),peak expiratory flow(PEF)]before and after surgery,serum SCC levels before and after surgery,and the incidence of postoperative complications were compared a-mong the three groups.Results The intraoperative blood loss in the single-port group,two-port group,and three-port group increased sequentially,with statistically significant differences(P<0.05).The NRS scores at 12,24,and 48 hours postoperatively in the single-port group were lower than those in the two-port and three-port groups,and the two-port group was lower than the three-port group,with statistically significant differences(P<0.05).Before surgery,no significant differences were observed in FEV1,FVC,and PEF among the three groups(P>0.05).At 4 months postoperatively,the FEV1 and FVC in all three groups were increased,and the single-port group was greater than the two-port and three-port groups,with significant differences(P<0.05);the PEF in all three groups was significantly faster than before surgery,and the single-port group was significantly faster than the two-port and three-port groups(P<0.05).Before surgery,no significant differences were noted in SCC levels among the three groups(P>0.05).At 7 days postoperatively,the SCC lev-els in all three groups showed significant decline,and the single-port group was significantly lower than the two-port and three-port groups(P<0.05).The incidence of postoperative complications in the single-port group was significantly lower than that in the two-port and three-port groups(P<0.05).Conclusion Compared with two-port and three-port thoraco-scopic lobectomy,single-port thoracoscopic lobectomy can better reduce intraoperative blood loss and the incidence of post-operative complications in elderly NSCLC patients,alleviate postoperative pain,improve pulmonary function,and lower postoperative serum SCC levels.
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