Effect of PED Flex on clinical efficacy,complication rate,and recurrence rate in patients with intracranial aneurysms of different diameters
Objective To explore the clinical efficacy of the Pipeline Flex Embolization Device(PED Flex)in patients with in-tracranial aneurysms of different diameters,as well as its impact on the incidence of complications and disease recurrence rates.Methods A total of 160 patients with intracranial aneurysms who visited a hospital in Hebei Province from January 2020 to January 2024 were selected as the study participants and assigned to a small/medium group(98 cases)and a large/giant group(62 cases)based on the size of the aneurysm diameter.Both groups were treated with PED Flex.The surgical perioperative indicators(surgical duration,hospital stay,hospital costs),prognosis(Glasgow Outcome Scale),aneurysm occlusion status(Raymond-Roy classification),National Institutes of Health Stroke Scale(NIHSS)scores,disease recur-rence rates,and complication rates were compared between the two groups.Results No significant differences were noted in surgical duration,hospital stay,and hospital costs between the two groups(P>0.05).One month after surgery,no sta-tistically significant difference was observed in the prognosis between the two groups(P>0.05).Six months after surgery,the Raymond-Roy classification in the small/medium group was grade I for 81 patients,grade Ⅱ for 14 patients,and gradeⅢ for 3 patients.In the large/giant group,it was grade I for 44 patients,grade Ⅱ for 8 patients,and grade Ⅲ for 10 pa-tients.A significant difference was found between the two groups(P<0.05).Compared to preoperative levels,the NIHSS scores of both groups decreased significantly six months after surgery(P<0.05);however,at different time points(preop-erative and six months postoperative),no significant differences were noted in NIHSS scores between the two groups(P>0.05).Within six months after surgery,the recurrence rate and complication rate in the small/medium group were signifi-cantly lower than those in the large/giant group(P<0.05).Conclusion PED Flex shows equivalent efficacy in treating in-tracranial aneurysms of different diameters,but the recurrence rate and postoperative complication rate are lower in small/medium aneurysms,indicating a higher safety profile.