首页|PED Flex对不同直径颅内动脉瘤患者临床疗效、并发症发生率及复发率的影响

PED Flex对不同直径颅内动脉瘤患者临床疗效、并发症发生率及复发率的影响

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目的 探讨Pipeline Flex血流导向装置(PED Flex)在不同直径颅内动脉瘤患者中的临床疗效,以及对患者并发症发生率、疾病复发率的影响.方法 选取2020年1月—2024年1月于河北省某医院就诊的160例颅内动脉瘤患者作为研究对象,按照动脉瘤直径大小分为中小型组(98例)、大型/巨大型组(62例),2组患者均使用PED Flex治疗.比较2组患者手术围术期指标(手术时长、住院时长、住院花费)、预后(格拉斯哥预后评分量表)、动脉瘤闭塞情况(Raymond-Roy分级)、美国国立卫生研究院卒中量表(NIHSS)评分、疾病复发率及并发症发生率.结果 2组患者手术时长、住院时长、住院花费比较,差异均无统计学意义(P>0.05).术后1个月,2组患者的预后比较,差异无统计学意义(P>0.05).术后6个月,中小型组患者Raymond-Roy分级Ⅰ级81人,Ⅱ级14人,Ⅲ级3人,大型/巨大型组患者Raymond-Roy分级Ⅰ级44人,Ⅱ级8人,Ⅲ级10人,2组比较,差异具有统计学意义(P<0.05).与术前比较,术后6个月2组患者的NIHSS评分均降低,差异均有统计学意义(P<0.05);但不同时间点(术前及术后6个月),2组患者间的NIHSS评分比较,差异均无统计学意义(P>0.05).术后6个月内,中小型组患者的复发率、并发症发生率均低于大型/巨大型组,差异均有统计学意义(P<0.05).结论 PED Flex治疗不同直径颅内动脉瘤显示出同等疗效,但中小型动脉瘤治疗后疾病复发率与术后并发症发生率更低,具有更高的安全性.
Effect of PED Flex on clinical efficacy,complication rate,and recurrence rate in patients with intracranial aneurysms of different diameters
Objective To explore the clinical efficacy of the Pipeline Flex Embolization Device(PED Flex)in patients with in-tracranial aneurysms of different diameters,as well as its impact on the incidence of complications and disease recurrence rates.Methods A total of 160 patients with intracranial aneurysms who visited a hospital in Hebei Province from January 2020 to January 2024 were selected as the study participants and assigned to a small/medium group(98 cases)and a large/giant group(62 cases)based on the size of the aneurysm diameter.Both groups were treated with PED Flex.The surgical perioperative indicators(surgical duration,hospital stay,hospital costs),prognosis(Glasgow Outcome Scale),aneurysm occlusion status(Raymond-Roy classification),National Institutes of Health Stroke Scale(NIHSS)scores,disease recur-rence rates,and complication rates were compared between the two groups.Results No significant differences were noted in surgical duration,hospital stay,and hospital costs between the two groups(P>0.05).One month after surgery,no sta-tistically significant difference was observed in the prognosis between the two groups(P>0.05).Six months after surgery,the Raymond-Roy classification in the small/medium group was grade I for 81 patients,grade Ⅱ for 14 patients,and gradeⅢ for 3 patients.In the large/giant group,it was grade I for 44 patients,grade Ⅱ for 8 patients,and grade Ⅲ for 10 pa-tients.A significant difference was found between the two groups(P<0.05).Compared to preoperative levels,the NIHSS scores of both groups decreased significantly six months after surgery(P<0.05);however,at different time points(preop-erative and six months postoperative),no significant differences were noted in NIHSS scores between the two groups(P>0.05).Within six months after surgery,the recurrence rate and complication rate in the small/medium group were signifi-cantly lower than those in the large/giant group(P<0.05).Conclusion PED Flex shows equivalent efficacy in treating in-tracranial aneurysms of different diameters,but the recurrence rate and postoperative complication rate are lower in small/medium aneurysms,indicating a higher safety profile.

PED FlexIntracranial aneurysmTherapeutic efficacyComplicationsRecurrence rate

贾文志、高晨淞、赵凤鸣、武海龙、刘宏雷

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河北省石家庄市第三医院神经外科,石家庄 050011

河北医科大学第一附属医院神经外科,石家庄 050011

Pipeline Flex血流导向装置 颅内动脉瘤 疗效 并发症 复发率

2024

保健医学研究与实践
西南大学

保健医学研究与实践

CSTPCD
影响因子:0.512
ISSN:1673-873X
年,卷(期):2024.21(10)