Objective To explore the clinical efficacy of the Pipeline Flex Embolization Device(PED Flex)in patients with in-tracranial aneurysms of different diameters,as well as its impact on the incidence of complications and disease recurrence rates.Methods A total of 160 patients with intracranial aneurysms who visited a hospital in Hebei Province from January 2020 to January 2024 were selected as the study participants and assigned to a small/medium group(98 cases)and a large/giant group(62 cases)based on the size of the aneurysm diameter.Both groups were treated with PED Flex.The surgical perioperative indicators(surgical duration,hospital stay,hospital costs),prognosis(Glasgow Outcome Scale),aneurysm occlusion status(Raymond-Roy classification),National Institutes of Health Stroke Scale(NIHSS)scores,disease recur-rence rates,and complication rates were compared between the two groups.Results No significant differences were noted in surgical duration,hospital stay,and hospital costs between the two groups(P>0.05).One month after surgery,no sta-tistically significant difference was observed in the prognosis between the two groups(P>0.05).Six months after surgery,the Raymond-Roy classification in the small/medium group was grade I for 81 patients,grade Ⅱ for 14 patients,and gradeⅢ for 3 patients.In the large/giant group,it was grade I for 44 patients,grade Ⅱ for 8 patients,and grade Ⅲ for 10 pa-tients.A significant difference was found between the two groups(P<0.05).Compared to preoperative levels,the NIHSS scores of both groups decreased significantly six months after surgery(P<0.05);however,at different time points(preop-erative and six months postoperative),no significant differences were noted in NIHSS scores between the two groups(P>0.05).Within six months after surgery,the recurrence rate and complication rate in the small/medium group were signifi-cantly lower than those in the large/giant group(P<0.05).Conclusion PED Flex shows equivalent efficacy in treating in-tracranial aneurysms of different diameters,but the recurrence rate and postoperative complication rate are lower in small/medium aneurysms,indicating a higher safety profile.
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