Analysis of the relationship between ALBI,PALBI Scores and liver fibrosis staging and inflammation grading in patients with chronic hepatitis B
Objective To explore the relationship between albumin-bilirubin(ALBI)and platelet-albumin-bilirubin(PALBI)scores and liver fibrosis staging and inflammation grading in patients with chronic hepatitis B(CHB),aiming to provide a reference for clinical treatment.Methods A total of 120 patients with CHB admitted to Longchang People's Hospital from March 2019 to March 2024 were selected as the study participants,who were grouped and compared based on their inflam-mation grading(G)and fibrosis staging(S).General information about the included participants was collected through med-ical records,including age,gender,body mass index,bilirubin,albumin,platelet count,aspartate aminotransferase(AST),and alanine aminotransferase(ALT).Results The ALBI and PALBI scores in the S4 group were higher than those in the S3,S2,and S0-1 groups;the scores in the S3 group were higher than those in the S2 and S0-1 groups;and the scores in the S2 group were higher than those in the S0-1 group,with significant differences(P<0.05).The ALBI and PALBI scores in the G4 group were higher than those in the G3,G2,and G0-1 groups;the scores in the G3 group were higher than those in the G2 and G0-1 groups;and the scores in the G2 group were higher than those in the G0-1 group,with statistically significant differences(P<0.05).Spearman correlation analysis showed that ALBI scores were positively correlated with liver fibrosis staging and inflammation grading in these patients(all P<0.05),and PALBI scores were also positively correlated with liver fibrosis staging and inflammation grading in CHB patients(all P<0.05).The results of multivariate logistic regression analysis indicated that ALBI score[OR(95%CI)=3.047(1.762-5.264)]and PALBI score[OR(95%CI)=3.804(2.000-7.235)]were influencing factors for liver fibrosis staging in CHB patients(P<0.05).Multivariate logistic regression analysis results indicated that ALBI score[OR(95%CI)=4.768(2.009-11.318)]and PALBI score[OR(95%CI)=3.920(2.057-7.470)]were independent influencing factors for inflammation grading in CHB patients(P<0.05).Conclusion ALBI and PALBI scores in CHB patients are closely correlated to liver fibrosis staging and inflammation grading.The increase in these scores can reflect the exacerbation of liver inflammation and fibrosis,which have the po-tential to serve as effective indicators for assessing liver fibrosis staging and inflammation grading in these patients.
万方数据
维普
