Relationship between serum C3a R1,BATF levels and the prognosis of patients with severe acute pancreatitis
Objective To explore the relationship between the levels of C3a receptor 1(C3a R1)and B-cell activating factor(BATF)and the prognosis of patients with severe acute pancreatitis,aiming to provide a reference for clinical treatment.Methods A total of 247 patients with acute pancreatitis treated at the First Affiliated Hospital of Xi'an Jiaotong University from June 2020 to June 2023 were selected as the study participants.Patients were assigned to a mild group(absence of or-gan failure and local complications,n=135)and a severe group(presence of persistent organ failure with local complica-tions,n=112).The 112 patients with severe acute pancreatitis were further assigned to a deterioration group(n=33)and an improvement group(n=79)based on their condition after 28 days of treatment.Additionally,140 healthy individuals who underwent physical examinations during the same period were included as the control group.The general information and levels of C3a R1 and BATF were compared among the groups.The receiver operating characteristic(ROC)curve was used to evaluate the predictive value of C3a R1 and BATF levels for the prognosis of patients with severe acute pancreatitis.Multivariate logistic regression analysis was used to identify factors affecting the prognosis of these patients.Results The Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)scores and white blood cell count(WBC),C-reac-tive protein(CRP),amylase(AMY),and lipase(LPS)levels in the severe group were higher than those in the mild group and the control group,while the albumin(Alb)level was lower than those in the mild group and the control group,with statistically significant differences(P<0.05).The APACHE Ⅱ scores and WBC,CRP,AMY,and LPS levels in the mild group were higher than those in the control group,while the Alb level was lower than that in the control group,with statis-tically significant differences(P<0.05).The levels of C3a R1 and BATF in the severe group were significantly higher than those in the mild group(P<0.05).ROC curve analysis showed that the area under the curve(AUC)(95%CI)for predic-ting the prognosis of severe acute pancreatitis using C3a R1,BATF,and their combination(in series)were 0.844(0.794-0.894),0.860(0.810-0.910),and 0.917(0.867-0.967),respectively.Binary logistic stepwise regression analysis re-sults indicated that an APACHE Ⅱ score>8.00(OR=2.617,95%CI:1.600～4.280)and C3a R1≥3.55 mg/L(OR=3.762,95%CI:1.947-7.269),BATF≥33.44 μg/L(OR=4.250,95%CI:2.002-9.022)were all risk factors affecting the prognosis of these patients(P<0.05).Conclusion The levels of C3a R1 and BATF are elevated in patients with severe a-cute pancreatitis,and the changes in these levels are closely correlated with the disease prognosis.They can serve as risk factors for poor prognosis in patients,and their combination has high clinical value in estimating the prognosis of these pa-tients.
Severe acute pancreatitisB-cell activating factorComplement C3a Receptor 1Disease prognosis
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