Relationship between red cell distribution width/platelet ratio and the condition and pregnancy outcomes in patients with gestational hypertension
Objective To explore the relationship between red cell distribution width/platelet ratio(RPR)and the condition and pregnancy outcomes in patients with gestational hypertension,aiming to provide a reference for clinical treatment.Methods A total of 138 patients with gestational hypertension treated at the Third Affiliated Hospital of Anhui Medical U-niversity from October 2020 to September 2023 were selected as the study participants.Patients were assigned to the gesta-tional hypertension group(n=62),mild preeclampsia group(n=45),and severe preeclampsia group(n=31)based on the severity of the condition.Follow-up was conducted until the end of pregnancy,and the patients were further assigned to the good outcome group(n=102)and the poor outcome group(n=36).The levels of red cell distribution width(RDW),platelet count(PLT),and RPR were compared among patients with different conditions and pregnancy outcomes.The re-ceiver operating characteristic(ROC)curve was used to assess the predictive value of RDW,PLT,and RPR for pregnancy outcomes.Multivariate stepwise regression analysis was used to explore the influencing factors of pregnancy outcomes in pa-tients with gestational hypertension.Results RDW and RPR gradually increased,and PLT gradually decreased in the gesta-tional hypertension group,mild preeclampsia group,and severe preeclampsia group,with statistically significant differences(P<0.05).Patients in the poor outcome group had higher RDW and RPR and lower PLT than those in the good outcome group,with statistically significant differences(P<0.05).The area under the curve(AUC)(95%CI)for predicting preg-nancy outcomes in patients with gestational hypertension by RDW,PLT,and RPR were 0.867(0.815-0.919),0.751(0.699-0.803),and 0.904(0.852-0.956),respectively.Multivariate stepwise regression analysis results indicated that age≥35 years,history of abortion,increased 24-hour urinary protein level,and RPR≥0.14 were independent risk factors for pregnancy outcomes in patients with gestational hypertension(P<0.05).Conclusion RPR levels in patients with ges-tational hypertension are correlated with the condition and pregnancy outcomes,and RPR can serve as an important indicator for predicting pregnancy outcomes in patients.
Red cell distribution widthPlateletsGestational hypertensionPregnancy outcomes