首页|红细胞分布宽度/血小板比值与妊娠期高血压患者病情、妊娠结局的关系

红细胞分布宽度/血小板比值与妊娠期高血压患者病情、妊娠结局的关系

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目的 探讨红细胞分布宽度/血小板比值(RPR)与妊娠期高血压患者病情、妊娠结局的关系,以期为临床治疗提供参考.方法 选取2020年10月—2023年9月安徽医科大学第三附属医院收治的138例妊娠期高血压患者作为研究对象.根据患者病情严重程度不同分为妊娠期高血压组(n=62例)、轻度子痫前期组(n=45例)、重度子痫前期组(n=31例).随访至妊娠结束,并将其分为结局良好组(n=102例)、结局不良组(n=36例).比较不同病情、妊娠结局的妊娠期高血压患者红细胞分布宽度(RDW)、血小板计数(PLT)、RPR水平;采用受试者工作特征(ROC)曲线评估RDW、PLT、RPR对妊娠结局的预测价值;采用多因素逐步回归分析探讨妊娠期高血压患者妊娠结局的影响因素.结果 妊娠期高血压组、轻度子痫前期组、重度子痫前期组患者RDW、RPR逐渐升高,PLT逐渐降低,差异均有统计学意义(P<0.05).结局不良组患者RDW、RPR高于结局良好组,PLT低于结局良好组,差异均有统计学意义(P<0.05).RDW、PLT、RPR预测妊娠期高血压患者妊娠结局的曲线下面积(AUC)(95%CI)分别为0.867(0.815~0.919)、0.751(0.699~0.803)、0.904(0.852~0.956).多因素逐步回归分析结果显示:年龄≥35岁、有流产史、24 h尿蛋白水平升高、RPR≥0.14是妊娠期高血压患者妊娠结局的独立危险因素(P<0.05).结论 妊娠期高血压患者RPR水平与其病情、妊娠结局有关,且RPR可作为预测患者妊娠结局的重要指标.
Relationship between red cell distribution width/platelet ratio and the condition and pregnancy outcomes in patients with gestational hypertension
Objective To explore the relationship between red cell distribution width/platelet ratio(RPR)and the condition and pregnancy outcomes in patients with gestational hypertension,aiming to provide a reference for clinical treatment.Methods A total of 138 patients with gestational hypertension treated at the Third Affiliated Hospital of Anhui Medical U-niversity from October 2020 to September 2023 were selected as the study participants.Patients were assigned to the gesta-tional hypertension group(n=62),mild preeclampsia group(n=45),and severe preeclampsia group(n=31)based on the severity of the condition.Follow-up was conducted until the end of pregnancy,and the patients were further assigned to the good outcome group(n=102)and the poor outcome group(n=36).The levels of red cell distribution width(RDW),platelet count(PLT),and RPR were compared among patients with different conditions and pregnancy outcomes.The re-ceiver operating characteristic(ROC)curve was used to assess the predictive value of RDW,PLT,and RPR for pregnancy outcomes.Multivariate stepwise regression analysis was used to explore the influencing factors of pregnancy outcomes in pa-tients with gestational hypertension.Results RDW and RPR gradually increased,and PLT gradually decreased in the gesta-tional hypertension group,mild preeclampsia group,and severe preeclampsia group,with statistically significant differences(P<0.05).Patients in the poor outcome group had higher RDW and RPR and lower PLT than those in the good outcome group,with statistically significant differences(P<0.05).The area under the curve(AUC)(95%CI)for predicting preg-nancy outcomes in patients with gestational hypertension by RDW,PLT,and RPR were 0.867(0.815-0.919),0.751(0.699-0.803),and 0.904(0.852-0.956),respectively.Multivariate stepwise regression analysis results indicated that age≥35 years,history of abortion,increased 24-hour urinary protein level,and RPR≥0.14 were independent risk factors for pregnancy outcomes in patients with gestational hypertension(P<0.05).Conclusion RPR levels in patients with ges-tational hypertension are correlated with the condition and pregnancy outcomes,and RPR can serve as an important indicator for predicting pregnancy outcomes in patients.

Red cell distribution widthPlateletsGestational hypertensionPregnancy outcomes

刘琳、刘荃、王剑南、赵金娟、苏坤丽、李笑天、韦芳琴

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安徽医科大学第三附属医院/安徽省合肥市第一人民医院滨湖院区妇产科,合肥 230041

复旦大学附属妇产科医院妇产科,上海 200001

红细胞分布宽度 血小板 妊娠期高血压 妊娠结局

2024

保健医学研究与实践
西南大学

保健医学研究与实践

CSTPCD
影响因子:0.512
ISSN:1673-873X
年,卷(期):2024.21(10)