Facile preparation of emamectin benzoate@alginate nanoparticles for controlled release
In order to reduce the use and impact of emamectin benzoate(EB)on the environment,nanoparticles were prepared by solvent diffusion method and coated with alginate(Alg)via electrostatic binding.The structure of the nanoparticles was characterized by FTIR,DLS and TEM,and related to the release behavior of EB.The results indicated that the size and the negative values of ζ-potential of EB@Alg nanoparticle increase with increasing Alg content,but decrease due to the crosslinking of the polymer chains by Ca2 cations.The increase of Alg and Ca2 benefit the encapsulation of EB,however leading to a lower loading efficiency in the nanoparticles.The release of EB is generally retarded by encapsulating into Alg-based nanoparticles and greatly influenced by the interaction with the polymer matrix.Competition binding of Ca cations on the polymer chains of Alg reduces the electrostatic interaction with EB and increases the diffusional release from the matrix.A better sustaining efficiency is obtained in the basic medium,due to the enhanced interaction with the active ingredient induced by the increased dissociation of carboxyl groups of Alg.
万方数据
维普
