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钩藤的药理作用及临床应用研究进展

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钩藤(Uncaria rhynchophylla)是广西区域特色药材品种之一,具有息风定惊、清热平肝的功效,药用历史悠久.钩藤生物碱是钩藤的主要药效成分,对缓解药物成瘾、阿尔茨海默症、高血压等疾病具有显著功效,其方药天麻钩藤饮、复方钩藤降压片等在临床上广泛应用.随着现代医学研究技术的进步,钩藤生物碱及其方药的治病机理正在不断被发现.本文收集近十年钩藤相关研究文献,以钩藤的药效物质为基础,总结钩藤生物碱及其方药的药理研究成果,分析钩藤的临床应用情况,以期为钩藤的新药研发或新应用提供理论借鉴.
Research Progress of Pharmacological Action and Clinical Appli-cation of Uncaria rhynchophylla
Uncaria rhynchophylla is one of the regional characteristic medicinal materials in Guangxi.It has a long history of medicinal use with the effects of calming the wind,clearing heat and soothing the liver.Uncar-ia alkaloids are the main effective components of U.rhynchophylla,which have significant effects on relieving drug addiction,Alzheimer's disease,hypertension and other diseases.Its prescriptions,such as Tianma Gout-eng Decoction and Compound Gouteng Hypotensive Tablets,are widely used in clinical practice.With the progress of modern medical research technology,the therapeutic mechanism of Uncaria alkaloids and its pre-scriptions is constantly being discovered.In this article,the related research literatures of U.rhynchophylla in recent ten years were collected.Based on the pharmacodynamic substances of U.rhynchophylla,the phar-macological research results of alkaloids and its prescriptions were summarized,and the clinical application of U.rhynchophylla was analyzed.It is expected to provide theoretical references for the new drug research and development or new application of U.rhynchophylla.

Uncaria rhynchophyllaalkaloidspharmacologyclinical application

谭桂玉、万凌云、张坤、彭凤、韦树根

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广西壮族自治区药用植物园,广西道地药材高品质形成与应用重点实验室/广西中药材良种繁育技术创新中心,广西南宁 530023

钩藤 生物碱 药理 临床应用

国家自然科学基金国家自然科学基金广西自然科学基金广西壮族自治区科技重大专项广西特色药材关键技术研究推广项目广西药用植物园科研项目广西中药材品质创新研究团队项目

82360753819037522019GXNSFBA185026桂科AA22096021GZKJ2314桂药基202013GZKJ2305

2024

广西科学
广西科学院 广西壮族自治区科学技术协会

广西科学

CSTPCD北大核心
影响因子:0.516
ISSN:1005-9164
年,卷(期):2024.31(1)
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