Acute Toxicity and Genotoxicity of Water Extract from Malus doumeri(Bois.)A.Chev.Leaves
The edible safety of the water extract from Malus doumeri(Bois.)A.Chev.leaves was examined by acute oral toxicity and genotoxicity tests.According to the experimental method of National Food Safety Standard-Procedure for Toxicological Evaluation of Food Safety,the toxicity of M.doumeri(Bois.)A.Chev.leaves was evaluated by acute toxicity and genotoxicity tests(including Ames test,mammalian erythro-cyte micronucleus test,and chromosome aberration test of mouse spermatogonia).The results showed that the median lethal dose(LD50)of the water extract from M.doumeri(Bois.)A.Chev.leaves was greater than 20 000 mg/kg BW.In the range of 8-5 000 μg/dish,the water extract showed a negative result in the Ames test.Within the dose range of 2 500-10 000 mg/kg BW,the water extract did not cause damage to mouse bone marrow erythrocytes or lead to chromosome aberration of mouse spermatogonia.According to the re-sults,the water extract of M.doumeri(Bois.)A.Chev.leaves was non-toxic and demonstrated no genotoxic-ity under the test conditions.
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