Assessment of Exposure and Inhalation Hazards of Organic Light-Emitting Materials Based on a Quantitative Structure-Property Relationship Model
Recent studies have shown that some Organic Light Emitting Materials(OLEMs)are persistent and bioaccumulative.With the aim of identifying the potential hazards of OLEMs to human health,patent re-trieval was carried out to establish a list of 1 988 OLEMs.A Quantitative Structure-Property Relationship(QSPR)model was developed based on the information of 94 OLEMs included in the Classification and Labe-ling Inventory(C&L Inventory).Euclidean distance,molecular descriptor standardization and kernel density estimation were employed to define the applicability domain of the model,and the potential exposure and in-halation hazards of 1 894 OLEMs that were not included in the C&L Inventory were predicted.The results indicated that 1 652 OLEMs might pose hazards to human health through exposure,while 1 612 OLEMs could potentially compromise human health via respiratory intake.The findings provide a theoretical basis for the identification of chemicals in prioritized control and the environmental management of emerging chemical substances.
Organic Light-Emitting Materials(OLEMs)quantitative structure-property relationshiphealth hazardkernel density estimation
万方数据
维普
