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植物乳杆菌GX17对雏鸡免疫及肠道功能的影响

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[目的]研究旨在探究比较植物乳杆菌GX17 与商品复合益生菌作为饲料添加剂时对黄羽肉鸡生长性能及肠道屏障功能的影响.[方法]将 225 只 1 d的雏鸡随机分为 3 组,植物乳杆菌(LP组),商品复合益生菌(S组)及对照组(Control组).LP组及S组分别在饮水中添加浓度为1.5×109 CFU/只鸡的植物乳杆菌GX17、商品复合益生菌制剂;C组正常饮水采食,试验为期 42 d.在整个试验期或不同时期测定生长参数、免疫学指标、十二指肠/空肠形态及空肠相关屏障基因.[结果]在整个试验期,补充植物乳杆菌GX17 和商品复合益生菌均能显著降低肉鸡的料重比,提高肉鸡的体液免疫功能,同时进一步增强新城疫疫苗免疫效果;显著提高绒毛高度与隐窝深度的比值,增强肠道对营养物质的吸收能力.与此之外,植物乳杆菌GX17 能显著上调CLDN、MUC2 以及TLR2的mRNA表达,商品复合益生菌能显著上调CLDN、Occludin、MUC2、TLR2 和TLR4 的mRNA表达,均能促进紧密连接,增强肠道屏障功能.[结论]与商品复合益生菌相比,植物乳杆菌GX17 对黄羽肉鸡的生长性能及肠道屏障功能具有相同的积极影响,可作为饲料添加剂应用于黄羽肉鸡养殖.
Effects of Lactobacillus Plantarum GX17 on Immunity and Intestinal Function of Chicks
[Objective]The purpose of this study was to explore and compare the effects of Lactobacillus plantarum GX17 and commercial compound probiotics as feed additives on growth performance and intestinal barrier function of yellow-feathered broilers.[Methods]One hundred and twenty-five 1-day-old chicks were randomly divided into three groups:Lactobacillus plantarum(group LP),commercial compound probiotics(group S)and control group(group C).Lactobacillus plantarum GX17 and commercial compound probiotics were added to the drinking water of 1.5×109CFU/chicks in group LP and group S,respectively,while those in group C were fed with normal drinking water for 42 days.The growth parameters,immunological indexes,duodenum/jejunum morphology and jejunum related barrier genes were measured during the whole or different periods of the experiment.[Results]During the whole experimental period,supplementation of Lactobacillus plantarum GX17 and commercial compound probiotics could significantly reduce the feed-to-weight ratio of broilers,improve the humoral immune function of broilers,further enhance the immune effect of Newcastle disease vaccine,significantly increase the ratio of villus length to crypt depth,and enhance the ability of intestinal absorption of nutrients.In addition,Lactobacillus plantarum GX17 significantly up-regulated the mRNA expression of CLDN,MUC2 and TLR2,and commercial compound probiotics could significantly up-regulate the expression of CLDN,Occludin,MUC2,TLR2 and TLR4,which could promote tight junction and enhance intestinal barrier function.[Conclusion]Compared with commercial compound probiotics,Lactobacillus plantarum GX17 has the same positive effect on growth performance and intestinal barrier function of yellow-feathered broilers,which can be used as feed additive in yellow-feathered broilers.

Lactobacillus plantarumyellow-feather broilersgrowth performanceimmunityintestinal function

彭昊、尹杨燕、朱敏、兰美益、李常挺、白慧丽、马春霞、王乐平、李晴晴、滕翎、谭奕舟、廖玉英

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广西兽医研究所广西兽医生物技术重点实验室,广西 南宁 530001

广西农业职业技术大学,广西 南宁 530007

广西大学,广西 南宁 530004

植物乳杆菌 黄羽肉鸡 生长性能 免疫 肠道功能

广西壮族自治区重点研发计划广西农业农村厅科技项目广西农业农村厅科技项目良庆区科技重大专项防城港市重点研发计划防城港市重点研发计划桂林市重点研发计划武鸣区重点研发项目江南区重点研发项目桂科专项桂科专项

AB21238003AB21220005-4Z202218Z202219202118AB21014016AB2001402820220136-52021010220220620-222-623-5

2024

广西农学报
广西农业广播电视学校

广西农学报

影响因子：0.322
ISSN：1003-4374
年,卷(期)：2024.39(1)
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