Objective To understand hepatitis B virus infection and related situations among pregnant women in Nanning city and analyze the related risk factors of hepatitis B virus(HBV)infection for pregnant women.Methods A total of 2 138 pregnant women who gave birth in Nanning Maternal and Child Health Hospital from April to September 2022 were selected.By collecting prenatal examination information,prenatal laboratory test data and on-site questionnaire surveys,the general information,demographic characteristics,hepatitis B vaccine immunization history,and other relevant data of the research subjects were analyzed.Results A total of 2 138 pregnant women who gave birth in hospital were investigated,192 of whom were HbsAg(+),with an HBV infection rate of 8.98％.The average age was(30.40±5.27)years old,and 1 859 women were vaccinated with hepatitis B vaccine,with a vaccination rate of 86.95％.The distribution of maternal pregnancy was 1-10 times,with quartile 2(1,3)times.The distribution of maternal pregnancy was 1-8 times,with quartile 2(1,2)times,and the distribution of prenatal check-ups was between 0-20 times,with quartile 11(9,12)times.With HBV infection marker HbsAg as the dependent variable,the logistic regression analysis showed that the age of subjects(P＜0.001,OR=1.072,95％CI=1.042-1.103),hepatitis B vaccination(P＜0.001,OR=0.350,95％CI=0.247-0.496),household registration(P=0.006,OR=1.710,95％CI=1.17-2.499),the number of pregnancies(P=0.001,OR=1.174,95％CI=1.07-1.288),the number of birth-giving(P＜0.001,OR=1.412,95％CI=1.187-1.679),educational level(compared with technical secondary school and below,high school and junior college P＜0.001,OR=0.319,95％CI=0.228-0.445;bachelor degree and above P＜0.001,OR=0.126,95％CI=0.067-0.236)were all associated with HBV infection in pregnant women.The results of multivariable analysis showed that the factors influencing HBV infection in pregnant women were maternal age(P=0.001,OR=1.056,95％CI=1.023-1.091),educational level(compared with technical secondary school and below,high school and junior college P＜0.001,OR=0.346,95％CI=0.246-0.486;bachelor degree and above P＜0.001,OR=0.146,95％CI=0.077-0.275),household registration(P=0.002,OR=1.903,95％CI=1.275-2.841),hepatitis B vaccination history(P＜0.001,OR=0.367,95％CI=0.255-0.528).There was a statistically significant difference in the hepatitis B virus infection rate among pregnant women in different age groups(x2=17.316,P=0.004).Conclusions Correcting the knowledge,attitudes and behaviors of women of childbearing age in high-risk areas for hepatitis B virus infection prevention and control,strengthening the education of hepatitis B prevention and control knowledge and hepatitis B vaccine immunization for this population is of great significance to reduce the infection rate of HBV in newborns.
pregnant womenhepatitis B virus infectionhepatitis B vaccine
NETL
NSTL
万方数据
