Objective To isolate and identify Salmonella from diarrhea case samples collected from Liuzhou sentinel hospitals and analyze their drug resistance and bacterial homology clustering,providing scientific basis for guiding clinical treatment medication and foodborne disease prevention and control,as well as promoting data support for tracing the source of sudden public health incidents caused by Salmonella.Methods The acute phase samples of diarrhea cases were collected from Liuzhou sentinel hospitals between 2021 and 2023.The isolated Salmonella were subjected to serotyping,drug sensitivity(drug sensitivity)tests,and pulsed field gel electrophoresis(PFGE)molecular typing.Results From 2021 to 2023,a total of 932 samples of diarrhea cases were collected,and 82 strains of Salmonella were detected,which were divided into 8 serotypes.Among them,55 strains of Salmonella typhimurium(67.07％)and 8 strains of Salmonella enteritis(9.76％)were found.The results of the selected 63 strains of Salmonella showed that the antibiotics with high resistance rates were ampicillin(76.19％),tetracycline(66.67％),and streptomycin(63.49％).All strains were sensitive to ceftazidime/avibactam.The resistance rate of Salmonella to 9 antibiotics had been increasing year by year from 2021 to 2023.There were 45 strains of multidrug-resistant bacteria,with a multidrug-resistant rate of 71.43％.The highest proportion of multidrug-resistant strains was found in the tetracycline-streptomycin-ampicillin(AMP-TET-STR)spectrum(46.67％).28 band patterns were resulted from PFGE typing,with a similarity between 3.42％and 100.00％.Among them,there were 2 groups of band patterns with a similarity of 100.00％,and only 2 groups of strains with a similarity greater than 85.00％.Conclusions The diarrhea cases caused by Salmonella in Liuzhou from 2021 to 2023 are mainly caused by Salmonella typhimurium,with no absolute dominant band in molecular typing.The resistance rate to some antibiotics has been increasing year by year.In the future,continuous monitoring of Salmonella molecular typing and its resistance should be further strengthened.
NETL
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万方数据
