Objective To retrospectively analyze on the occurrence of suspected adverse events following immunization(AEFI)before and after the COVID-19 vaccine and hepatitis B vaccine(with 60 days)in Hubei province,and evaluate the safety of COVID-19 vaccine and Hepatitis B vaccine before and after inoculation.Methods The case data of people aged 3 and above with records of vaccination before and after the COVID-19 vaccine and hepatitis B vaccine(within 60 days)from 2020 to 2022 were screened out from the"Hubei Province Immunization Program Information System"and matched with the case information of the"AEFI Information System".The incidence of AEFI was used as the evaluation index,and descriptive epidemiological methods were used to analyze the characteristics of AEFI.Results From 2020 to 2022,a total of 581 337 doses of COVID-19 vaccine and hepatitis B vaccine were administered before and after vaccination(within 60 days)in people aged 3 years and older in Hubei province,with a total of 157 AEFI cases reported,and the overall incidence of AEFI was 0.270‰(rare).The incidence of AEFI before and after vaccination with hepatitis B vaccine(CHO)and COVID-19 vaccine(adenovirus vector)was the highest(5.629‰).The incidence of AEFI were significantly different among different vaccine combinations(x2=23.737,P=0.014).The incidence of AEFI was the highest in the central region(0.395‰),and the incidence of AEFI in different regions were significantly different(x2=29.892,P＜0.001).There were no significant difference in the incidence of AEFI between different time intervals before and after vaccination(P＞0.05).Among the general reactions,the incidence of clinically diagnosed fever,redness,and induration were the highest(0.229‰).The incidence of AEFI in different clinical diagnoses were statistically significant(x2=384.375,P＜0.001).In abnormal reactions and couplings,there were no significant difference in the incidence in different clinical diagnoses(P＞0.05).In terms of population distribution,there were no significant difference in the incidence of AEFI between different genders(P＞0.05).The incidence of AEFI was the highest in the age group from 3～＜18 years old(0.158‰).The incidence of AEFI in different age groups were statistically significant(x2=85.473,P＜0.001).The incidence of AEFI was the highest in children with childcare occupation(0.100‰),there were statistical significance in the incidence of AEFI among different occupations(x2=116.380,P＜0.001).Conclusions The incidence of AEFI is rare when COVID-19 vaccine and Hepatitis B vaccine before and after inoculation(within 60 days),and the vaccines can be inoculated at the same time with safety.
COVID-19 Vaccinehepatitis B vaccinebefore and after inoculationsafety
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