Objective To observe the clinical effect of Zero-P system applied in anterior cervical surgery,and to investigate the advantages of ZERO-P system in the treatment of cervical radiculopathy.Methods A retrospective analysis was per-formed on 58 cases of cervical radiculopathy admitted to the spinal surgery department of Sanmenxia Hospital of the Yellow River from October 2020 to December 2022.The patients were grouped according to different surgical methods,28 cases in the observation group received anterior cervical Zero-P system internal fixation,and 30 cases in the control group received titanium plate+fusion device internal fixation.The amount of intraoperative blood loss,operation time,hospital stay,postoperative JOA score,pain VAS score,Odom score,Cobb Angle,vertebral space height,cervical physiological curvature and responsible seg-ment curvature were compared between the two groups.Results All 58 cases were followed up for 14-24 months.The amount of blood loss,operation time and hospital stay in the observation group were lower than those in the control group,and the differ-ences were statistically significant(P<0.05).There was no significant difference in JOA score and pain VAS score at the last follow-up between the two groups(P>0.05).In the observation group,the Odom score was excellent in 19 cases,good in 8 cases and fair in 1 case,with an excellent and good rate of 96.4%(27/28).In the control group,the Odom score was excellent in 13 cases,good in 11 cases and fair in 6 cases,with an excellent and good rate of 80.0%(24/30).Postoperative dysphagia occurred in 1 case in the observation group and 3 cases in the control group.Postoperative dysphagia in the observation group was better than that in the control group,and the difference was statistically significant(P<0.05).There were no significant differences in Cobb Angle and vertebral space height at 3 months and the last follow-up between the two groups(P>0.05).There were no sig-nificant differences in cervical physiological curvature and responsible segment curvature at 3 days,1 month,3 months and the last follow-up between the two groups(P>0.05).There were no dysphagia symptoms at the last follow-up in the two groups,no loosening or displacement of the internal fixation in the observation group.The posterior displacement of the fusion apparatus oc-curred in 1 case in the control group,but no second operation was needed for the time being according to cervical spine CT+3D.Conclusion The treatment of cervical radiculopathy with anterior cervical Zero-P system has satisfactory results,with short operation time,less intraoperative bleeding and short hospital stay.