Objective To observe the feasibility and effectiveness of bone cement preloading plugging technology in percutane-ous kyphoplasty for osteoporotic thoracolumbar compression fractures in the elderly.Methods A total of 36 patients(36 verte-bral bodies)with osteoporotic thoracolumbar compression fractures(the compression collapse height of the fractured vertebral body reached one third of the original vertebral height)who were treated with percutaneous kyphoplasty from June 2022 to June 2023 were enrolled.Among them,18 cases were treated with bone cement preloading plugging technology(observation group),while another 18 cases were treated with conventional technique(control group).The VAS score,ODI index,anterior edge height of injured vertebra,and Cobb angle of injured vertebra were compared between the two groups at 1 day and 3 months af-ter operation.Results Thirty-six cases received follow-up,from 4 to 6 months after operation,on average 4.6 months.There was no significant difference in operation time between the observation group and the control group(P>0.05).One case of bone cement leakage was found in the observation group,and 2 cases of bone cement leakage were found in the control group.All pa-tients had no symptoms of nerve injury.There was no significant difference in VAS score and ODI index between the observa-tion group and the control group on the first day and 3 months after operation(P>0.05).The height of the anterior edge of the in-jured vertebra in the observation group was higher than that in the control group at 1 day and 3 months after operation,and the Cobb angle of the injured vertebra in the observation group was lower than that in the control group at 1 day and 3 months after operation,and the differences were statistically significant(P<0.05).Conclusion The application of bone cement preloading plugging technology in percutaneous kyphoplasty for osteoporotic thoracolumbar compression fractures is safe and effective.It can significantly relieve thoracolumbar back pain,maintain the height of the vertebral body after reduction,and improve kyphosis.