Objective To observe the early clinical effect and second arthroscopic exploration of LARS artificial ligament com-bined with hamstring tendon for anterior cruciate ligament reconstruction.Methods A retrospective analysis was performed on 57 cases of single bundle anterior cruciate ligament reconstruction performed in the Department of Orthopedics,First Affiliated Hospital of Xiamen University from January 2017 to September 2020.The patients were divided into the observation group and the control group according to the graft types selected during reconstruction.Twenty-nine cases in the observation group under-went hollow LARS artificial ligament combined with autologous hamstring tendon.The control group of 28 patients received au-tologous hamstring tendon.Knee function Lysholm score,knee function IKDC score,knee function Tegner score,return to exer-cise and second arthroscopic exploration were compared between the two groups at 3 months,6 months and 12 months after sur-gery.Results All patients were followed up for at least 12 months.At the last follow-up,the anterior drawer test and Lachman test were negative in both groups,and there were no complications such as joint infection,rejection reaction,and deep venous thrombosis of lower limbs.Lysholm score of knee function,IKDC score of knee function and Tegner score of knee function at 3 months,6 months and 12 months after surgery were significantly higher than those before surgery,and continued to improve,with statistical significance(P<0.05).Lysholm score of knee function,IKDC score of knee function and Tegner score of knee function in the observation group at 3 months and 6 months after surgery were significantly improved compared with the control group,with statistical significance(P<0.05).There was no significant difference in Lysholm score,IKDC score and Tegner score of knee function between the two groups 12 months after surgery(P>0.05).There was no significant difference in the pro-portion of return to exercise between the two groups(P>0.05).However,the proportion of return to competitive sports in the ob-servation group was higher than that in the control group,and the difference was statistically significant(P<0.05).There were significant differences between the two groups in the timing of returning to light sports,no confrontation sports and competitive sports(P<0.05).The second arthroscopic exploration time of the two groups was between 12-18 months,and the excellent rate of synovial coverage was 96.6%in the observation group and 96.4%in control group;there was no significant difference in sy-novial coverage between the two groups(P>0.05).Conclusion The use of LARS ligaments combined with autologous tendons for ACL reconstruction can help patients recover knee joint function faster,return to sports earlier,and have a higher return rate to competitive sports,and the second arthroscopic exploration found no significant difference in synovium coverage compared with conventional autologous tendon reconstruction of ACL.