Comparative Study on the Synthesis Process of Sofinaxin Succinate
In this paper,different routes of sofenacin succinate were studied and compared.By comparison,it was found that after the departure group(Lv)was introduced from(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline,it was esterification reaction with(R)-3-quininocyclol to form salt,with a total yield of about 90%,which has obvious advantages.It not only has a high yield,but also has good product quality,and is more suitable for industrial production.
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维普
