Study on the Improvement of Mouse Intestinal Microflora by Composite Probiotic Powder
In order to investigate the improvement effects of composite probiotic powder and the raw materials and excipients that make up the powder on the intestinal microbiota of mice,this experiment used low,medium,and high dose groups of composite probiotic powder,as well as the raw materials and excipients groups,to orally administer male SPF grade Babl/c mice for 30 days.Weekly weight measurements were conducted on mice,and feces were collected on day 0,day 14,and day 30,respectively.The gut microbiota(Enterococcus,Enterobacterium,Clostridium perfringens,Lactobacillus,and Bifidobacterium)in the feces were cultured and counted.During the experiment,there were no significant abnormalities in the mental state,activity,feeding,and excretion of all mice,and their weight continued to increase.The research results of the gut microbiota before and after the experiment showed that there was a significant difference in the gut microbiota of the composite probiotic powder group before and after intervention,and there was also a significant difference between the intervention group and the negative control group.This is mainly manifested as a significant increase in Bifidobacteria and Lactobacilli in mouse feces,with better effects than the raw material group and auxiliary material group;Enterobacterium,Enterococcus,and Clostridium perfringens were significantly reduced,and their inhibitory effect on the growth of harmful bacteria was better than that of the raw material group and auxiliary material group.In summary,composite probiotic powder helps to improve the function of mouse gut microbiota,and the improvement effect of composite probiotic powder on gut microbiota is better than that of the individual raw material group and excipient group.
万方数据
维普
