Discovery and Detection of Gut Microbiota and Inflammatory Bowel Disease Targets
The research aims to reveal the relationship between gut microbiota and Inflammatory Bowel Disease(IBD),and to search for new detection methods and therapeutic targets.The study used C57BL/6 mice as experimental models to establish an acute colitis model,and different treatment methods were used for the mice,including Hydrostatin-SN10,infliximab(IFX),and Hydrostatin-SN10 mutant peptide.The paper observed and record relevant data daily for each group of mice.Both the experimental and treatment groups showed weight loss,with the DSS experimental group showing the greatest weight loss.On the 7th day,the weight of the mice was 15.4±0.2 g,the levels of Chymotrypsin C,RhoGDI2 and Gelsolin in the colon of mice in the experimental group were significantly increased,while those in the treatment group were decreased.The study provides new perspectives and experimental data to understand the relationship between gut microbiota and inflammatory bowel disease,as well as the possible association between Hydrostatin-SN10 and the treatment of IBD.
Gut microbiotaInflammatory bowel diseaseDSSC57BL/6 mice
万方数据
维普
