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单细胞测序数据的生物信息学分析方法与应用

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单细胞测序技术是一项新技术.文章从单细胞测序技术的基本原理和发展历程入手,突出其在生物医学领域的重要性,详细探讨生物信息学分析的关键步骤,包括数据预处理、细胞异质性分析、基因表达分析以及轨迹推断和空间基因组学等高级技术,阐述单细胞测序在癌症研究、发育生物学、免疫学和神经科学等领域的应用,揭示其在理解细胞异质性和生物过程动态中的核心作用.文章旨在为研究人员提供有关单细胞测序技术及其分析方法的全面概述,展望其在生物医学研究领域的广阔应用前景.
Research on Bioinformatics Analysis Methods and Applications of Single Cell Sequencing Data
Single cell sequencing technology is a new technology.Starting from the basic principles and development history of single-cell sequencing technology,this paper highlights its importance in the field of biomedical science.The paper explores in detail the key steps of bioinformatics analysis,including data preprocessing,cell heterogeneity analysis,gene expression analysis,trajectory inference,and advanced technologies such as spatial genomics.It elaborates on the applications of single-cell sequencing in cancer research,developmental biology,immunology,and neuroscience.Subsequently,the paper reveals its core role in understanding cellular heterogeneity and biological process dynamics.This aims to provide researchers with a comprehensive overview of single-cell sequencing technology and its analytical methods,and to explore its broad application prospects in biomedical research.

single cell sequencingbioinformaticsdevelopmental biologydata analysistechnical challenges

张晓帅、李红亚

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许昌电气职业学院,河南许昌 461000

单细胞测序 生物信息学 发育生物学 数据分析 技术挑战

2024

工业微生物
全国工业微生物信息中心 上海市工业微生物研究所

工业微生物

影响因子:0.293
ISSN:1001-6678
年,卷(期):2024.54(2)
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