摘要
微生物依赖信号识别和信号传递来感知并响应外界环境变化.c-di-AMP作为第二信使分子在信号传导过程中发挥着关键作用,其通过酶、转录调控因子和核糖开关等受体靶标来调控细胞生长、生物膜形成、K+稳态、DNA完整性、细胞壁合成和脂肪酸合成等与生理功能相关的基因和蛋白的表达.尽管对于c-di-AMP代谢调控在枯草芽孢杆菌、单增李斯特氏菌和金黄色葡萄球菌等细菌中的研究较为深入,但对其在乳酸菌中的研究却相对较少.基于此,文章重点关注乳酸菌中c-di-AMP的代谢及其在K+稳态和抑制甘氨酸甜菜碱转运中的信号传导作用;同时,通过总结现有研究中的乳酸菌c-di-AMP代谢调控,深化对乳酸菌第二信使分子信号调控的认知.
Abstract
Microorganisms rely on the signal recognition and transmission to answer the external environment change.c-di-AMP,as the second messenger molecule,plays a key role in signal transmission.It regulates the genes and proteins expression related to the physiological functions such as cell growth,biofilm formation,potassium homeostasis,DNA integrity,cell wall synthesis and fatty acid synthesis via receptor targets such as enzymes,transcriptional regulators and riboswitches.Although the regulation of c-di-AMP metabolism has been well studied in bacteria such as Bacillus subtilis,Listeria monocytogenes and Staphylococcus aureus,there is reletively less research in lactic acid bacteria.This paper focuses on the metabolism of c-di-AMP in lactic acid bacteria and the signaling role of c-di-AMP in potassium homeostasis and inhibition of glycine-betaine transport,and summarizes the metabolic modulation of c-di-AMP in lactic acid bacteria in current research,in order to deepen the understanding of the signal regulation of second messenger molecular in lactic acid bacteria.
基金项目
国家自然科学基金面上项目(32272300)
上海市自然科学基金面上项目(22ZR1444000)
维普
万方数据