Establishment of a Method for Determination of Residual Solvent in Estradiol
The paper established a headspace gas chromatography method and simultaneously determined the residual solvents methanol and ethanol in estradiol.The paper uses a capillary column with 6％cyanopropyl and 94％dimethylpolysiloxane as stationary phases as the chromatographic column,and is detected by a hydrogen flame ionization detector.The methodological validation results indicate that methanol ranges from 2.01 to 20.1 μ.The linear relationship is good within the range of g/mL(r=0.999 8),and ethanol ranges from 2.00 to 24.0 µ.The linear relationship is good within the range of g/mL(r=0.999 8);The recovery rates of methanol are 106.9％,102.2％,and 100.8％,respectively,while the recovery rates of ethanol are 104.3％,103.8％,and 105.9％.This method has strong specificity,high sensitivity,and good accuracy,and can be used for the determination of residual solvents in estradiol.
万方数据
维普
