首页|基于肠道微生物-炎症代谢途径探讨大黄黄连泻心汤加减方有效成分的实验研究

基于肠道微生物-炎症代谢途径探讨大黄黄连泻心汤加减方有效成分的实验研究

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肠道微生物与宿主的炎症代谢途径之间的交互作用在健康和疾病发展中发挥着重要的调控作用。文章通过对大黄黄连泻心汤加减方中的有效成分进行研究,探讨其在肠道微生物与炎症代谢途径调控中的作用。同时,通过多种研究方法,揭示了该方剂中关键成分对肠道微生物多样性和菌群组成的影响,并证实了其对主要炎症标志物的调节能力,进一步揭示了这些成分主要是通过调节相关途径上的基因表达和蛋白质水平来发挥作用的。研究结果为深入理解大黄黄连泻心汤加减方的功效提供了实验依据,也为今后研究新的治疗方法提供了思路。
Research on the Active Components of Modified Dahuang-Huanglian-Xiexin Decoction Based on the Intestinal Microbiota-Inflammatory Metabolic Pathways
The interaction between intestinal microorganisms and the inflammatory metabolic pathways of the host plays an important regulatory role in health and disease development.This paper explores the role of the active components of modified Dahuang-Huanglian-Xiexin decoction in the regulation of intestinal microorganisms and inflammatory metabolic pathways by studying the active components of this prescription.Through the applications of a variety of research methods,the effects of key components in the prescription on intestinal microbial diversity and flora composition are revealed,and the ability of these components to regulate major inflammatory markers is confirmed.Further analysis reveals that these components plays a role by regulating gene expression and protein levels in related pathways.The results of this study provide an experimental basis for the deep understanding of the efficacy of modified Dahuang-Huanglian-Xiexin decoction,and provide ideas for future research on new treatment methods.

intestinal microorganismsinflammatory metabolic pathwaysmodified Dahuang-Huanglian-Xiexin decoctionactive componentsregulation

宋爽

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甘肃卫生职业学院,甘肃兰州 730207

肠道微生物 炎症代谢途径 大黄黄连泻心汤加减方 有效成分 调控

甘肃卫生职业学院2023年校级课题

202302

2024

工业微生物
全国工业微生物信息中心 上海市工业微生物研究所

工业微生物

影响因子:0.293
ISSN:1001-6678
年,卷(期):2024.54(3)