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微生物发酵中菌丝结球影响因素的研究进展

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在微生物发酵过程中,诸多产品只有在丝状菌丝结球的情况下才能产生其所需要的次级代谢产物;还有一些产品在菌丝结球的情况下能够有效减少发酵动力消耗,有利于控制成本。菌丝结球的影响因素复杂且综合,涵盖了菌种的遗传特性、质量和接孢量、进入发酵罐前种子的种龄和移种量、培养基中各种营养成分的比例,以及发酵过程中的溶氧、搅拌转速、空气流量等工艺控制参数。基于此,文章对发酵过程中菌丝结球影响因素的研究进行系统介绍。
Research on Influencing Factors of the Mycelium Pellet in Fermentation Process
In the fermentation process,many products can only produce the required secondary metabolites with the conditions of mycelium pellets;while the other products can effectively reduce the fermentation energy consumption with the conditions of mycelium pellets,which is beneficial for cost control.The affecting factors of the mycelium pellets are comprehensive,including the genetic factors of bacterial strains,quality and spore inoculation of bacterial strains,seed age and inoculation volume before entering the fermentation tank,the nutrient components in the culture medium,dissolved oxygen,stirring speed,air flow and other parameters in the fermentation process.This paper systematically introduces the research on the influencing factors of the mycelium pellet in fermentation process.

bacterial strainfermentationmycelium pelletsecondary metabolism

郑玲辉、陈伟、陈令伟

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杭州中美华东制药有限公司,浙江杭州 310011

杭州珲益生物科技有限公司,浙江杭州 310011

菌种 发酵 菌丝结球 次级代谢

2024

工业微生物
全国工业微生物信息中心 上海市工业微生物研究所

工业微生物

影响因子:0.293
ISSN:1001-6678
年,卷(期):2024.54(3)
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