Mechanism Analysis and Molecular Docking Verification of the Treatment of Thromboangitis Obliterans with Camptosru Sibiricus Based on the Network Pharmacology
By using the network pharmacology and molecular docking technology,the potential mechanism of Camptosru sibiricus in treating thromboangitis obliterans has been explored.The main effective components of Camptosru sibiricus were obtained through literature review,and the prediction targets of thromboangitis obliterans were obtained from GeneCards,CTD and OMIM databases.Intersecting the potential targets points of Camptosru sibiricus and the predicted target points of thromboangitis obliterans,potential targets for Camptosru sibiricus in treating thromboangitis obliterans were obtained.The"component of Camptosru sibiricus-treatment of thromboangitis obliterans-target network"was constructed in Cytascape.The target functions were enriched by useing the DAVID platform.With the help of Autodock and PyMOL software,the molecular docking verification of the target and its corresponding active components were carried out.There were 9 possible main effective components of Camptosru sibiricus in treating thromboangitis obliterans,and 31 corresponding potential targets.The enrichment of KEGG pathway resulted in 103 signal pathways,mainly involving AGE-RAGE signal pathway,lipid and atherosclerosis,tumor necrosis factor signal pathway,HIF-1 signal pathway,neutrophil extracellular trap formation and other channels in diabetes complications.The Camptosru sibiricus may play a role in the treatment of thromboangitis obliterans by influencing the biological processes such as leukocyte-cell adhesion,positive regulation of nitric oxide biosynthesis,platelet activation,cell surface,plasma membrane,extracellular space,enzyme binding,receptor binding,heparin binding,and regulating the expression of multiple target genes,so as to provide a scientific basis for Camptosru sibiricus in treating thromboangitis obliterans.
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