Effect of Intestinal Dysbacteriosis on the Number of Th17 Cells in the Spleen and Thymus of Mice
Th17 is typically present in the gut in a microbe-dependent manner and plays a crucial role in maintaining the integrity and stability of intestinal barrier.When the intestinal flora is abnormal,the number of Th17 cells will change,leading to intestinal diseases and immune imbalances.The artide employed a microbial dysbiosis model in mice by administering a combination of antibiotics and examined the percentage of Th17 cells in the thymus and spleen of mice in experimental and control groups by flow cytometry.It was observed that the mice in the experimental group exhibited a notable decline in weight during the initial phase of mixed antibiotic feeding,which gradually recovered in the subsequent stage.The results of flow cytometry demonstrated a notable decline in the percentage of Th17 cells in the thymus and spleen of the experimental group of mice,exhibiting a reduction of 47.70％and 23.83％,respectively,in comparison to the control group.These findings indicated that the intestinal dysbacteriosis of mice resulting from mixed antibiotic feeding can contribute to a reduction in the number of Th17 cells in the thymus and spleen of mice.
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