The application value of andrographolide can be further developed by using the new preparation technique.In this study,andrographolide nano-lipid carriers were synthesized by using the melt-emulsification-ultrasonication-low temperature solidification method with process parameters improved.The ideal circumstances were a compound of glyceryl monostearate and isopropyl myristate,Tween-80 as a surfactant,a solid-to-liquid lipid ratio of 1∶1,The drug-lipid ratio was 1∶20 and emulsified for 60 min in a 75℃ water bath.This study can provide a theoretical basis for further development of andrographolide.
维普
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