The Antioxidant Effect of Polyphenols of Anji White Tea on D-galactose Induced Aging Model Mice
Objective:To discuss the antioxidant effect of polyphenols of Anji White Tea on D-galactose induced aging model mice.Method:72 Male ICR mice were randomly divided into normal group,D-galactose model group,and low,medium and high dose of Anji White tea polyphenols group,Vc group.Except the normal group,the mice in other groups were given D-galactose by injection to establish the aging mice model.At the same time of establishing the model,the mice in drug groups were given the corresponding concentration of drug with the method of gavage,while the normal group and model group were given the same amount of normal saline in the same way.After 35 days,weighted the mice and collected the blood.Separated the serum and measured the organ indexes.SOD activity and MDA content in serum and brain tissue were determined.Results:Compared with the normal group,the weight of the model group mice and the content of MDA in their brain tissues and serum increased significantly,while part of their organ indexes and SOD activity decreased (P ＜ 0.01).Compared with model group,the organ indexes of kidney and spleen of the mice in all Anji White tea polyphenols groups increased significantly(P ＜ 0.01),while the serum of all groups' mice and the SOD activity of the mice in high dose group increased significantly (P ＜ 0.01).The brain tissue neutralization in different doses' group and the MDA in the serum in high dose group decreased significantly (P ＜ 0.01).All these suggest that Anji White Tea polyphenols have good antioxidant effect.Conclusion:Anji White Tea polyphenols in midium and high dose group can improve the antioxidant ability of aging mice induced by D-galactose,and its mechanism may be related to inhibit the generation of lipid peroxide,enhance the activity of antioxidant enzymes.
Anji White Tea polyphenolsD-galactoseantioxidant activity
NETL
NSTL
万方数据
维普
